PMID- 32259839
OWN - NLM
STAT- MEDLINE
DCOM- 20210722
LR  - 20210722
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Print)
IS  - 2047-2404 (Linking)
VI  - 22
IP  - 1
DP  - 2021 Jan 1
TI  - The relation between cardiac 123I-mIBG scintigraphy and functional response 1 
      year after CRT implantation.
PG  - 49-57
LID - 10.1093/ehjci/jeaa045 [doi]
AB  - AIMS: Cardiac resynchronization therapy (CRT) is a disease-modifying therapy in 
      patients with chronic heart failure (CHF). Current guidelines ascribe CRT 
      eligibility on three parameters only: left ventricular ejection fraction (LVEF), 
      QRS duration, and New York Heart Association (NYHA) functional class. However, 
      one-third of CHF patients does not benefit from CRT. This study evaluated whether 
      123I-meta-iodobenzylguanidine (123I-mIBG) assessed cardiac sympathetic activity 
      could optimize CRT patient selection. METHODS AND RESULTS: A total of 78 stable 
      CHF subjects (age 66.8 +/- 9.6 years, 73% male, LVEF 25.2 +/- 6.7%, QRS duration 
      153 +/- 23 ms, NYHA 2.2 +/- 0.7) referred for CRT implantation were enrolled. 
      Subjects underwent 123I-mIBG scintigraphy prior to implantation. Early and late 
      heart-to-mediastinum (H/M) ratio and 123I-mIBG washout were calculated. CRT 
      response was defined as either an increase of LVEF to >35%, any improvement in 
      LVEF of >10%, QRS shortening to <150 ms, or improvement in NYHA class of >1 
      class. In 33 patients LVEF increased to >35%, QRS decreased <150 ms in 36 
      patients, and NYHA class decreased in 33 patients. Late H/M ratio and 
      hypertension were independent predictors of LVEF improvement to >35% (P = 0.0014 
      and P = 0.0149, respectively). In addition, early H/M ratio, LVEF, and absence of 
      diabetes mellitus (DM) were independent predictors for LVEF improvement by >10%. 
      No independent predictors were found for QRS shortening to <150 ms or improvement 
      in NYHA class. CONCLUSION: Early and late H/M ratio were independent predictors 
      of CRT response when improvement of LVEF was used as measure of response. 
      Therefore, cardiac 123I-mIBG scintigraphy may be used as a tool to optimize 
      selection of subjects that might benefit from CRT.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Verschure, D O
AU  - Verschure DO
AD  - Department of Radiology and Nuclear Medicine, Amsterdam University Medical 
      Centers, Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 
      9, 1105 AZ Amsterdam, the Netherlands.
AD  - Department of Cardiology, Zaans Medical Center, Koningin Julianaplein 58, 1502 DV 
      Zaandam, the Netherlands.
FAU - Poel, E
AU  - Poel E
AD  - Department of Radiology and Nuclear Medicine, Amsterdam University Medical 
      Centers, Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 
      9, 1105 AZ Amsterdam, the Netherlands.
FAU - De Vincentis, G
AU  - De Vincentis G
AD  - Department of Radiological Sciences, Oncology and Anatomo-Pathology, "Sapienza" 
      University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.
FAU - Frantellizzi, V
AU  - Frantellizzi V
AD  - Department of Radiological Sciences, Oncology and Anatomo-Pathology, "Sapienza" 
      University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.
FAU - Nakajima, K
AU  - Nakajima K
AD  - Department of Functional Imaging and Artificial Intelligence, Kanazawa 
      University, 13-1 Takara-machi, Kanazawa 920-8640, Japan.
FAU - Gheysens, O
AU  - Gheysens O
AD  - Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc, 
      Hippokrateslaan 10, 1200 Brussels, Belgium.
FAU - de Groot, J R
AU  - de Groot JR
AD  - Heart Center, Department of Cardiology, Amsterdam University Medical Centers, 
      Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 9, 1105 
      AZ Amsterdam, the Netherlands.
FAU - Verberne, H J
AU  - Verberne HJ
AD  - Department of Radiology and Nuclear Medicine, Amsterdam University Medical 
      Centers, Location Amsterdam Medical Center, University of Amsterdam, Meibergdreef 
      9, 1105 AZ Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
RN  - 8YWR746RPQ (Iodine-123)
SB  - IM
MH  - 3-Iodobenzylguanidine
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Female
MH  - *Heart Failure/diagnostic imaging/therapy
MH  - Humans
MH  - Iodine Radioisotopes
MH  - Male
MH  - Middle Aged
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC7758029
OTO - NOTNLM
OT  - 123I-mIBG scintigraphy
OT  - cardiac resynchronization therapy
OT  - chronic heart failure
OT  - heart-to-mediastinum ratio
OT  - response
OT  - wash out
EDAT- 2020/04/08 06:00
MHDA- 2021/07/23 06:00
PMCR- 2020/04/07
CRDT- 2020/04/08 06:00
PHST- 2019/11/22 00:00 [received]
PHST- 2020/01/21 00:00 [revised]
PHST- 2020/03/10 00:00 [accepted]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2021/07/23 06:00 [medline]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/07 00:00 [pmc-release]
AID - 5817454 [pii]
AID - jeaa045 [pii]
AID - 10.1093/ehjci/jeaa045 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2021 Jan 1;22(1):49-57. doi: 
      10.1093/ehjci/jeaa045.