PMID- 32260122 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2076-2615 (Print) IS - 2076-2615 (Electronic) IS - 2076-2615 (Linking) VI - 10 IP - 4 DP - 2020 Apr 3 TI - The Oxidative Stress Markers of Horses-the Comparison with Other Animals and the Influence of Exercise and Disease. LID - 10.3390/ani10040617 [doi] LID - 617 AB - Diacron-reactive oxygen metabolite (d-ROM) and biological antioxidant potential (BAP) levels in the serum of horses were measured (ponies, n = 15; thoroughbred, n = 31; other full-sized horses, n = 7). The mean d-ROM levels in horses were significantly higher (p < 0.001) than those in dairy cattle (n = 25) and dogs (n = 31). However, d-ROM levels in horses were lower than the standard levels reported in humans. When d-ROM and BAP levels were plotted graphically, the points for horses with a disease (ringbone in 1 Japanese sports horse, cellulitis in 1 thoroughbred, melanoma in 1 Lipizzaner) fell outside the group of points for other (non-diseased) horses. A similar separation was seen (using data from other authors) for a horse with Rhodococcus equi, a horse following castration surgery, and a mare following delivery. These results, comparing horses, other animals, and humans, are interesting from the standpoint of comparative medicine, and they contribute to the sparse literature available on d-ROM and BAP levels in animals. Because the level of d-ROM and BAP levels were changed depending on the situation of health, those indexes are promising as indices of health in horses. FAU - Shono, Saori AU - Shono S AD - Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan. FAU - Gin, Azusa AU - Gin A AD - Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan. FAU - Minowa, Fumiko AU - Minowa F AD - Minowa Horse Clinic, Tokyo 144-0033, Japan. FAU - Okubo, Kimihiro AU - Okubo K AD - Department of Otolaryngology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan. FAU - Mochizuki, Mariko AU - Mochizuki M AD - Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan. LA - eng GR - 23580430/the Ministry of Education, Science, Sports, Culture and Technology of Japan. :/ PT - Journal Article DEP - 20200403 PL - Switzerland TA - Animals (Basel) JT - Animals : an open access journal from MDPI JID - 101635614 PMC - PMC7222798 OTO - NOTNLM OT - biological antioxidant potential OT - diacron-reactive oxygen metabolite OT - horse OT - oxidative stress index COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2020/04/09 06:00 MHDA- 2020/04/09 06:01 PMCR- 2020/04/03 CRDT- 2020/04/09 06:00 PHST- 2020/02/28 00:00 [received] PHST- 2020/03/28 00:00 [revised] PHST- 2020/04/02 00:00 [accepted] PHST- 2020/04/09 06:00 [entrez] PHST- 2020/04/09 06:00 [pubmed] PHST- 2020/04/09 06:01 [medline] PHST- 2020/04/03 00:00 [pmc-release] AID - ani10040617 [pii] AID - animals-10-00617 [pii] AID - 10.3390/ani10040617 [doi] PST - epublish SO - Animals (Basel). 2020 Apr 3;10(4):617. doi: 10.3390/ani10040617.