PMID- 32260508
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 4
DP  - 2020 Apr 5
TI  - Comparison of Clinical Outcomes between Hyaluronic and Polylactic Acid Filler 
      Injections for Penile Augmentation in Men Reporting a Small Penis: A Multicenter, 
      Patient-Blinded/Evaluator-Blinded, Non-Inferiority, Randomized Comparative Trial 
      with 18 Months of Follow-up.
LID - 10.3390/jcm9041024 [doi]
LID - 1024
AB  - Although several types of penile augmentation (PA) fillers have been recently 
      introduced, no long-term follow-up studies have compared them. This study aimed 
      to compare the long-term clinical outcomes of hyaluronic acid (HA) and polylactic 
      acid (PLA) filler injections for PA. Our multicenter, 
      patient-blinded/evaluator-blinded, randomized comparative trial was performed for 
      18 months after the single injection of fillers. Sixty-seven healthy men 
      reporting a small penis were administered an injection between November 2016 and 
      May 2017. Subjects were divided into the HA group (n = 33) and PLA group (n = 
      34). At 18 months, the mean penile girths had significantly increased in both 
      groups (each p < 0.001). Changes in the mean penile girth of both groups were not 
      significantly different during the study period. Satisfaction levels at 18 months 
      were significantly higher than those at baseline in both groups (each p < 0.01). 
      Changes in satisfaction levels did not differ significantly during the study 
      period. Injection-associated adverse events (AEs) occurred in three (9.1%) 
      patients in the HA group and in two (5.9%) patients in the PLA group; no serious 
      AEs occurred. In conclusion, HA and PLA filler injections for PA led to 
      significant augmentation and increased satisfaction. Clinical efficacy and safety 
      were comparable between groups.
FAU - Yang, Dae Yul
AU  - Yang DY
AD  - Department of Urology, College of Medicine, Hallym Unversity, Kangdong Sacred 
      Heart Hospital, Seoul 05355, Korea.
FAU - Jeong, Hyun Cheol
AU  - Jeong HC
AD  - Department of Urology, College of Medicine, Hallym Unversity, Kangdong Sacred 
      Heart Hospital, Seoul 05355, Korea.
FAU - Ko, Kyungtae
AU  - Ko K
AD  - Department of Urology, College of Medicine, Hallym Unversity, Kangdong Sacred 
      Heart Hospital, Seoul 05355, Korea.
FAU - Lee, Seong Ho
AU  - Lee SH
AD  - Department of Urology, College of Medicine, Hallym Unversity, Dongtan Sacred 
      Heart Hospital, Hwaseong 18450, Korea.
FAU - Lee, Young Goo
AU  - Lee YG
AD  - Department of Urology, College of Medicine, Hallym Unversity, Kangnam Sacred 
      Heart Hospital, Seoul 07441, Korea.
FAU - Lee, Won Ki
AU  - Lee WK
AD  - Department of Urology, College of Medicine, Hallym Unversity, Chuncheon Sacred 
      Heart Hospital, Chuncheon 24253, Korea.
LA  - eng
GR  - CMDHA0101/Cha Meditech Co., Ltd./
PT  - Journal Article
DEP - 20200405
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7230452
OTO - NOTNLM
OT  - augmentation
OT  - filler
OT  - hyaluronic acid
OT  - men
OT  - penis
OT  - polylactic acid
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/09 06:00
MHDA- 2020/04/09 06:01
PMCR- 2020/04/05
CRDT- 2020/04/09 06:00
PHST- 2020/02/25 00:00 [received]
PHST- 2020/04/02 00:00 [revised]
PHST- 2020/04/03 00:00 [accepted]
PHST- 2020/04/09 06:00 [entrez]
PHST- 2020/04/09 06:00 [pubmed]
PHST- 2020/04/09 06:01 [medline]
PHST- 2020/04/05 00:00 [pmc-release]
AID - jcm9041024 [pii]
AID - jcm-09-01024 [pii]
AID - 10.3390/jcm9041024 [doi]
PST - epublish
SO  - J Clin Med. 2020 Apr 5;9(4):1024. doi: 10.3390/jcm9041024.