PMID- 32260517
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 9
IP  - 4
DP  - 2020 Apr 5
TI  - Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, 
      Nutrient Antioxidants and Inflammation-Related Biomarkers.
LID - 10.3390/antiox9040301 [doi]
LID - 301
AB  - (1) Background: Little is known about the interlinkages between dietary and 
      plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and 
      the body's antioxidant and inflammation response. Our aim was to explore these 
      associations in 210 participants from two Spanish European Prospective 
      Investigation into Cancer and Nutrition (EPIC) centers. (2) Methods: D-NEAC was 
      estimated using published NEAC values in food. P-NEAC and total polyphenols (TP) 
      were quantified by FRAP (ferric-reducing antioxidant power), TRAP (total 
      radical-trapping antioxidant parameter), TEAC-ABTS (trolox equivalent antioxidant 
      capacity - Azino Bis Thiazoline Sulfonic), ORAC (oxygen radical absorbance 
      capacity) and Folin-Ciocalteu assays. Nutrient antioxidants (carotenes, 
      alpha-tocopherol, ascorbic acid, retinol, uric acid, Q9 and Q10 coenzymes) and 
      inflammation markers (IL-6, IL-8, CRP, TNF-alpha, PAI-I, resistin and adiponectin) 
      were also analyzed. Spearman correlation and linear regression analyses were 
      performed in association analyses. Analyses were stratified by covariates and 
      groups were defined using cluster analysis. (3) Results: P-FRAP was correlated 
      with D-NEAC, and significantly associated with P-NEAC in multivariate adjusted 
      models. P-FRAP levels were also significantly associated with plasma antioxidants 
      (log2 scale: TP beta = 0.26; ascorbic acid beta = 0.03; retinol beta = 0.08; alpha-tocopherol 
      beta = 0.05; carotenes beta = 0.02; Q10 beta = 0.06; uric acid beta = 0.25), though not with 
      inflammation-related biomarkers. Different profiles of individuals with varying 
      levels of P-NEAC and biomarkers were found. (4) Conclusions: P-NEAC levels were 
      to some extent associated with D-NEAC and plasma antioxidants, yet not associated 
      with inflammation response.
FAU - Carrion-Garcia, Cayetano Javier
AU  - Carrion-Garcia CJ
AD  - Department of Nutrition and Bromatology, Faculty of Pharmacy, University of 
      Granada, Campus Universitario de Cartuja S/N, 18071 Granada, Spain.
AD  - Nutrition and Food Science Doctorate Program (RD 99/2011), University of Granada, 
      18012, Spain.
FAU - Guerra-Hernandez, Eduardo Jesus
AU  - Guerra-Hernandez EJ
AD  - Department of Nutrition and Bromatology, Faculty of Pharmacy, University of 
      Granada, Campus Universitario de Cartuja S/N, 18071 Granada, Spain.
FAU - Garcia-Villanova, Belen
AU  - Garcia-Villanova B
AD  - Department of Nutrition and Bromatology, Faculty of Pharmacy, University of 
      Granada, Campus Universitario de Cartuja S/N, 18071 Granada, Spain.
FAU - Serafini, Mauro
AU  - Serafini M
AD  - Functional Food and Metabolic Prevention Lab, Faculty of BioSciences and 
      Technology for Food, Agriculture and Environment, University of Teramo, 64100 
      Teramo, Italy.
FAU - Sanchez, Maria Jose
AU  - Sanchez MJ
AUID- ORCID: 0000-0003-4817-0757
AD  - Andalusian School of Public Health, Instituto de Investigacion Biosanitaria 
      ibs.GRANADA, Univeristy Hospital of Granada/University of Granada, 18011 Granada, 
      Spain.
AD  - CIBER Epidemiologia y Salud Publica, CIBERESP (Centro de Investigacion 
      Biomedica), 28029 Madrid, Spain.
FAU - Amiano, Pilar
AU  - Amiano P
AD  - CIBER Epidemiologia y Salud Publica, CIBERESP (Centro de Investigacion 
      Biomedica), 28029 Madrid, Spain.
AD  - Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, 20014 
      Donostia-San Sebastian, Spain.
FAU - Molina-Montes, Esther
AU  - Molina-Montes E
AD  - Andalusian School of Public Health, Instituto de Investigacion Biosanitaria 
      ibs.GRANADA, Univeristy Hospital of Granada/University of Granada, 18011 Granada, 
      Spain.
AD  - CIBER Epidemiologia y Salud Publica, CIBERESP (Centro de Investigacion 
      Biomedica), 28029 Madrid, Spain.
AD  - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre 
      (CNIO), Madrid, and CIBER Oncology, CIBERONC, 28029 Madrid, Spain.
LA  - eng
GR  - PI12/00002/Instituto de Salud Carlos III/
GR  - PI12/00002/European Regional Development Fund/
PT  - Journal Article
DEP - 20200405
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC7222170
OTO - NOTNLM
OT  - antioxidant status
OT  - dietary antioxidants
OT  - inflammatory markers
OT  - oxidative stress
OT  - total antioxidant capacity
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/09 06:00
MHDA- 2020/04/09 06:01
PMCR- 2020/04/05
CRDT- 2020/04/09 06:00
PHST- 2020/03/21 00:00 [received]
PHST- 2020/03/31 00:00 [revised]
PHST- 2020/04/03 00:00 [accepted]
PHST- 2020/04/09 06:00 [entrez]
PHST- 2020/04/09 06:00 [pubmed]
PHST- 2020/04/09 06:01 [medline]
PHST- 2020/04/05 00:00 [pmc-release]
AID - antiox9040301 [pii]
AID - antioxidants-09-00301 [pii]
AID - 10.3390/antiox9040301 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2020 Apr 5;9(4):301. doi: 10.3390/antiox9040301.