PMID- 32260801
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 1
IP  - 9
DP  - 2013 Mar 7
TI  - Magnetic mesoporous bioactive glass scaffolds: preparation, physicochemistry and 
      biological properties.
PG  - 1279-1288
LID - 10.1039/c2tb00262k [doi]
AB  - The magnetic 10Fe5Ca MBG scaffolds (Fe(3)O(4)-CaO-SiO(2)-P(2)O(5) system) have 
      been prepared by a combination of polyurethane sponge and P123 as co-templates 
      and an evaporation-induced self-assembly (EISA) process through the substitution 
      of Fe(3)O(4) for CaO in the 15Ca MBG scaffolds (CaO-SiO(2)-P(2)O(5) system). The 
      structure, magnetic heating, drug release, physicochemical and biological 
      properties were systematically investigated. The results showed that the 10Fe5Ca 
      MBG scaffolds had the interconnected macroporous structure with pore sizes 
      ranging from 200 to 400 mum and the mesoporous wall with a peak pore size of ca. 
      3.34 nm. Also, the 10Fe5Ca MBG scaffolds exhibited similar mechanical strength, 
      apatite-forming ability and sustained drug release behavior compared to the 15Ca 
      MBG scaffolds. Importantly, the substitution of Fe(3)O(4) for CaO in the MBG 
      scaffolds induced a slower ion dissolution rate and more significant potential to 
      stabilize the pH environment, and facilitated osteoblast cell proliferation, 
      alkaline phosphatase (ALP) activity and osteogenic expression. In particular, the 
      10Fe5Ca MBG scaffolds could generate heat in an alternating magnetic field. 
      Therefore, the magnetic 10Fe5Ca MBG scaffolds have potential for the regeneration 
      of the critical-size bone defects caused by bone tumors by a combination of 
      magnetic hyperthermia and local drug delivery therapy.
FAU - Zhu, Yufang
AU  - Zhu Y
AD  - School of Materials Science and Engineering, University of Shanghai for Science 
      and Technology, 516 Jungong Road, Shanghai, 200093, China. zjf2412@163.com.
FAU - Shang, Fangjian
AU  - Shang F
FAU - Li, Bo
AU  - Li B
FAU - Dong, Yu
AU  - Dong Y
FAU - Liu, Yunfei
AU  - Liu Y
FAU - Lohe, Martin R
AU  - Lohe MR
FAU - Hanagata, Nobutaka
AU  - Hanagata N
FAU - Kaskel, Stefan
AU  - Kaskel S
LA  - eng
PT  - Journal Article
DEP - 20130122
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2013/03/07 00:00
MHDA- 2013/03/07 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2013/03/07 00:00 [pubmed]
PHST- 2013/03/07 00:01 [medline]
AID - 10.1039/c2tb00262k [doi]
PST - ppublish
SO  - J Mater Chem B. 2013 Mar 7;1(9):1279-1288. doi: 10.1039/c2tb00262k. Epub 2013 Jan 
      22.