PMID- 32260897
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 1
IP  - 15
DP  - 2013 Apr 21
TI  - Nano-p-n junction heterostructure TiO(2) nanobelts for the electrochemical 
      detection of anticancer drug and biointeractions with cancer cells.
PG  - 2072-2077
LID - 10.1039/c3tb00227f [doi]
AB  - Nano-p-n junction heterostructures based on TiO(2) nanobelts with enhanced (001) 
      facets were produced by assembling p-type semiconductor NiO nanoparticles on 
      n-type surface-coarsened TiO(2) nanobelt surfaces. The heterostructures were then 
      used as the sensing electrode for the electrochemical detection of anticancer 
      drugs O(6)-benzylguanine (O(6)BG) and lung cancer cells. O(6)BG exhibited an 
      irreversible diffusion-controlled electrochemical process with an oxidation peak 
      clearly identified at +0.78 V. For lung cancer cells one oxidation peak was found 
      at +1.1 V and two reduction peaks at +0.30, and +0.90 V. These voltammetric 
      features disappeared when O(6)BG was added to the lung cancer cells, which was 
      ascribed to the structural changes of the cell membranes caused by the anticancer 
      drug. These results suggested that nano-p-n junction heterostructures based on 
      TiO(2) nanobelts might serve as promising candidates for biosensing applications 
      of anticancer drugs and tumor cells that will be of significance in diagnostic 
      medicine, cancer diagnosis and molecular biology research.
FAU - Cui, Jingjie
AU  - Cui J
AD  - College of Life Information Science & Instrument Engineering, Hangzhou Dianzi 
      University, Hangzhou 310018, China. cuijingjie@hdu.edu.cn.
FAU - Ge, Yakun
AU  - Ge Y
FAU - Chen, Shaowei
AU  - Chen S
FAU - Zhao, Hongshi
AU  - Zhao H
FAU - Liu, Hong
AU  - Liu H
FAU - Huang, Zhen
AU  - Huang Z
FAU - Jiang, Huaidong
AU  - Jiang H
FAU - Chen, Jing
AU  - Chen J
LA  - eng
PT  - Journal Article
DEP - 20130305
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2013/04/21 00:00
MHDA- 2013/04/21 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2013/04/21 00:00 [pubmed]
PHST- 2013/04/21 00:01 [medline]
AID - 10.1039/c3tb00227f [doi]
PST - ppublish
SO  - J Mater Chem B. 2013 Apr 21;1(15):2072-2077. doi: 10.1039/c3tb00227f. Epub 2013 
      Mar 5.