PMID- 32261000
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 1
IP  - 44
DP  - 2013 Nov 28
TI  - Preparation, characterization, and in vitro evaluation of folate-modified 
      mesoporous bioactive glass for targeted anticancer drug carriers.
PG  - 6147-6156
LID - 10.1039/c3tb20867b [doi]
AB  - Functionalized mesoporous bioactive glasses (MBGs) with folic acid (FA) were 
      evaluated specifically for targeting cancer cells because of the high abundance 
      of folate receptors (FRs) in numerous cancer cells. The folate-modified MBG 
      (MBG-FA) was used as a targeted anticancer drug delivery carrier to investigate 
      receptor-mediated targeting characteristics. At the same time, in vitro 
      cytotoxicity and cell uptake of FA-grafted MBG (MBG-FA) to HeLa and L929 cell 
      lines were evaluated. MBG-FA was nontoxic up to a concentration of 200 mug mL(-1), 
      and can be specifically raised by HeLa and L929 cells through FA 
      receptor-mediated endocytosis. In vitro cellular uptakes of MBG-FA were 
      investigated with a fluorescence microscope, which demonstrates considerably 
      higher internalization of the MBG-FA by HeLa epithelial carcinoma cells, which 
      are overexpressed folate receptors (FRs), than the cellular uptake by L929 
      fibroblast cells, which are deficient folate receptors (FRs). Camptothecin (CPT), 
      a water-insoluble anticancer drug, was delivered into cancer cells; surface 
      conjugation with cancer-specific targeting agents increased the uptake into 
      cancer cells relative to non-cancerous fibroblasts. CPT had a sustained release 
      pattern from MBG-FA, and the CPT-loaded MBG-FA exhibited greater cytotoxicity 
      than free CPT because of the increased cell uptake of anticancer drug delivery 
      vehicles mediated by the FA receptor. The structural, morphological, and textural 
      features were characterized well by X-ray diffraction (XRD), transmission 
      electron microscopy (TEM), and N(2) adsorption/desorption. The results reveal 
      that the MBG exhibited typical ordered characteristics of the hexagonal 
      mesostructure. Therefore, this study concludes that the MBG-FA system 
      demonstrates great potential in the targeted intelligent drug delivery systems 
      (DDSs) and cancer-therapy fields.
FAU - Lin, Hsiu-Mei
AU  - Lin HM
AD  - Institute of Bioscience and Biotechnology, National Taiwan Ocean University, 2 
      Pei Ning Road, Keelung, Taiwan 20224, Republic of China. hmlin@mail.ntou.edu.tw.
FAU - Lin, Hung-Yi
AU  - Lin HY
FAU - Chan, Ming-Hsien
AU  - Chan MH
LA  - eng
PT  - Journal Article
DEP - 20131010
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2013/11/28 00:00
MHDA- 2013/11/28 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2013/11/28 00:00 [pubmed]
PHST- 2013/11/28 00:01 [medline]
AID - 10.1039/c3tb20867b [doi]
PST - ppublish
SO  - J Mater Chem B. 2013 Nov 28;1(44):6147-6156. doi: 10.1039/c3tb20867b. Epub 2013 
      Oct 10.