PMID- 32261810
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 2
IP  - 38
DP  - 2014 Oct 14
TI  - Mesoporous organosilica hybrids with a tunable amphoteric framework for 
      controlled drug delivery.
PG  - 6487-6499
LID - 10.1039/c4tb00808a [doi]
AB  - The chemical conversion of nitrile groups integrated in the pore wall frameworks 
      of mesoporous organosilica hybrids (MSHs) into either carboxylic acid groups or 
      amine groups by an acid or base hydrolysis method without altering the 
      mesostructural order is suggested. By this approach, bifunctional derivatives 
      could be produced in the silica pore walls. The nitrile groups integrated 
      covalently into the pore walls of the mesoporous organosilica hybrids were 
      converted to reactive functionalities, such as carboxylic acid (-COOH) or amine 
      (-NH(2)) groups, by treatment with H(2)SO(4) or LiAlH(4) as the catalytic 
      reagents. This facile approach allows the production of high amounts of either 
      -COOH groups (3.26 mmol g(-1)) or amine (-NH(2)) groups (4.13 mmol g(-1)) into 
      the pore walls of the mesoporous organosilica hybrids. The synthesised materials 
      were characterised by X-ray diffraction, N(2) sorption isotherms, Fourier 
      transform infrared spectroscopy, transmission electron microscopy (TEM), scanning 
      electron microscopy (SEM) and solid state (13)C cross-polarization magic angle 
      spinning nuclear magnetic resonance spectroscopy (CP MAS NMR). Owing to the 
      presence of hydrophilic basic diurea functional groups and -COOH or -NH(2) 
      derivatives in the pore walls, the obtained samples could behave like 
      bifunctional materials. The mesoporous organosilica hybrids with chemically 
      derivatised carboxylic acid groups or amine functionalities in the pore wall 
      frameworks were found to be suitable drug carriers for the controlled delivery of 
      both hydrophilic (for example, 5-FU) and hydrophobic (e.g. IBU) drugs under an 
      intracellular environment. The biocompatibility of the synthesised materials was 
      also evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 
      (MTT) assay. The cellular uptake was monitored by confocal laser scanning 
      microscopy (CLSM). These results show that the synthesised materials have 
      potential use as efficient carriers for drug delivery applications.
FAU - Moorthy, Madhappan Santha
AU  - Moorthy MS
AD  - Department of Polymer Science and Engineering, Pusan National University, Busan 
      609-735, Korea. csha@pnu.edu.
FAU - Park, Ji-Hye
AU  - Park JH
FAU - Bae, Jae-Ho
AU  - Bae JH
FAU - Kim, Sun-Hee
AU  - Kim SH
FAU - Ha, Chang-Sik
AU  - Ha CS
LA  - eng
PT  - Journal Article
DEP - 20140820
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2014/10/14 00:00
MHDA- 2014/10/14 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2014/10/14 00:00 [pubmed]
PHST- 2014/10/14 00:01 [medline]
AID - 10.1039/c4tb00808a [doi]
PST - ppublish
SO  - J Mater Chem B. 2014 Oct 14;2(38):6487-6499. doi: 10.1039/c4tb00808a. Epub 2014 
      Aug 20.