PMID- 32262231
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 3
IP  - 17
DP  - 2015 May 7
TI  - Viscosity enhanced release (VER) effect in nanoporous drug delivery systems: 
      phenomenon and mechanism.
PG  - 3483-3489
LID - 10.1039/c5tb00267b [doi]
AB  - High viscosity is important for normal intracellular homeostasis. In this study, 
      nanoporous drug delivery systems (DDSs), including mesoporous silica 
      nanoparticles (MSNs) and layer by layer (LBL) microcapsules, with a viscosity 
      enhanced release (VER) effect were designed and prepared, and their drug release 
      behaviors in a sticky environment with a high viscosity were investigated using 
      rhodamine B, methylene blue and doxorubicin (DOX) as model drugs. The results 
      showed that the drug release rate from DDSs in a biomimetic high viscosity 
      solution was 7 to 8 times higher than that in water. A semipermeable membrane 
      model was used to explain the VER effect. The results indicate that the existence 
      of macromolecules in the release medium caused a VER effect. The VER effect found 
      in this study will provide a new concept to guide the design of DDSs in a high 
      viscosity environment in vivo.
FAU - Zheng, Di-Wei
AU  - Zheng DW
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan 430072, P. R. China. xz-zhang@whu.edu.cn.
FAU - Li, Jiang-Lan
AU  - Li JL
FAU - Li, Cao
AU  - Li C
FAU - Xu, Zu-Shun
AU  - Xu ZS
FAU - Cheng, Si-Xue
AU  - Cheng SX
FAU - Zhang, Xian-Zheng
AU  - Zhang XZ
LA  - eng
PT  - Journal Article
DEP - 20150324
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2015/05/07 00:00
MHDA- 2015/05/07 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2015/05/07 00:00 [pubmed]
PHST- 2015/05/07 00:01 [medline]
AID - 10.1039/c5tb00267b [doi]
PST - ppublish
SO  - J Mater Chem B. 2015 May 7;3(17):3483-3489. doi: 10.1039/c5tb00267b. Epub 2015 
      Mar 24.