PMID- 32262642
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 3
IP  - 38
DP  - 2015 Oct 14
TI  - Injection-molded hydroxyapatite/polyethylene bone-analogue biocomposites via 
      structure manipulation.
PG  - 7585-7593
LID - 10.1039/c5tb00643k [doi]
AB  - Due to insufficient mechanical performance, such as low tensile strength, the 
      application of hydroxyapatite (HA)/high-density polyethylene (HDPE) biocomposites 
      has been limited to use as minor load-bearing bone substitutes. In the current 
      work, we propose to impose an intense shear flow during injection molding to tune 
      the microstructure of the HA/HDPE biocomposites, by which an anisotropic 
      biomimetic structure and superior mechanical properties were gained. 
      Morphological observations manifested that the imposed intense shear induced a 
      large amount of oriented self-reinforced superstructure, i.e., interlocked 
      shish-kebabs, which brought not only structure similarity with the natural bone 
      but also considerable mechanical reinforcement. For the 20 wt% HA/HDPE 
      biocomposite, the tensile strength and bending strength of the structured sample 
      rose from 22.4 and 20.2 MPa for the normal sample to 60.4 and 44.0 MPa, 
      increasing by 169% and 118%, respectively, which already reaches the bounds of 
      human cortical bone. The Young's modulus increased to 1462.0 MPa, with an augment 
      of 37%. The impact toughness of the structured biocomposite (64.6 kJ m(-2)) 
      showed as over 5 times larger than the normal biocomposite (10.1 kJ m(-2)). 
      Besides, the dispersion of the HA in the biocomposites especially at the high 
      filler content was enhanced, playing a positive role in sustaining the 
      bioactivity. All these results indicate that the structured HA/HDPE biocomposites 
      hold great promise for use in high load-bearing orthopedic applications.
FAU - Wang, Ze-Pu
AU  - Wang ZP
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu, 610065, People's Republic of 
      China. jzxu@scu.edu.cn ganji.zhong@scu.edu.cn.
FAU - Huang, Yan-Fei
AU  - Huang YF
FAU - Xu, Jia-Zhuang
AU  - Xu JZ
FAU - Niu, Ben
AU  - Niu B
FAU - Zhang, Xiao-Liang
AU  - Zhang XL
FAU - Zhong, Gan-Ji
AU  - Zhong GJ
FAU - Xu, Ling
AU  - Xu L
FAU - Li, Zhong-Ming
AU  - Li ZM
LA  - eng
PT  - Journal Article
DEP - 20150903
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2015/10/14 00:00
MHDA- 2015/10/14 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2015/10/14 00:00 [pubmed]
PHST- 2015/10/14 00:01 [medline]
AID - 10.1039/c5tb00643k [doi]
PST - ppublish
SO  - J Mater Chem B. 2015 Oct 14;3(38):7585-7593. doi: 10.1039/c5tb00643k. Epub 2015 
      Sep 3.