PMID- 32262810
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 4
IP  - 1
DP  - 2016 Jan 7
TI  - Gallium-containing mesoporous bioactive glass with potent hemostatic activity and 
      antibacterial efficacy.
PG  - 71-86
LID - 10.1039/c5tb02062j [doi]
AB  - Haemorrhage remains the leading cause of potentially survivable death in both 
      military and civilian populations. Although a large variety of hemostatic agents 
      have been developed, many of them have an inadequate capacity to induce 
      hemostasis and are not effective in killing bacteria. In recent years, mesoporous 
      bioactive glasses (MBGs) were found to be effective in inducing hemostasis. 
      However, the materials may not be considered as ideal hemostats since they do not 
      offer antimicrobial activity. The gallium ion (Ga(+3)) not only exhibits 
      antibacterial properties but also accelerates the blood coagulation cascade. The 
      aim of this study was to develop MBGs containing various concentrations of 
      Ga(2)O(3) (1, 2 & 3 mol%) via the evaporation-induced self-assembly (EISA) 
      process and investigate whether the addition of Ga(3+) would induce both 
      hemostatic and antibacterial effects. The results indicated that the 
      incorporation of lower Ga(2)O(3) content (1 mol%) into the MBG system improved 
      structural properties including the specific surface area, mesopore size and pore 
      volume as well as the release of silicon and calcium ions. The bioactive glass 
      was found to stimulate blood coagulation, platelet adhesion and thrombus 
      generation and exerted an antibacterial effect against both Escherichia coli and 
      Staphylococcus aureus. Likewise, Ga-doped MBGs showed excellent cytocompatibility 
      even after 3 days, with the 1% Ga(2)O(3)-containing MBG attaining the best 
      biocompatibility that render them safe hemostatic agents for stopping bleeding. 
      This study demonstrated that the lowest Ga(2)O(3)-substituted MBG can be a potent 
      candidate for controlling haemorrhage and wound infection.
FAU - Pourshahrestani, Sara
AU  - Pourshahrestani S
AD  - Department of Biomedical Engineering, Faculty of Engineering, University of 
      Malaya, Kuala Lumpur 50603, Malaysia.
FAU - Zeimaran, Ehsan
AU  - Zeimaran E
FAU - Adib Kadri, Nahrizul
AU  - Adib Kadri N
FAU - Gargiulo, Nicola
AU  - Gargiulo N
FAU - Samuel, Shani
AU  - Samuel S
FAU - Naveen, Sangeetha Vasudevaraj
AU  - Naveen SV
FAU - Kamarul, Tunku
AU  - Kamarul T
FAU - Towler, Mark R
AU  - Towler MR
LA  - eng
PT  - Journal Article
DEP - 20151127
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2016/01/07 00:00
MHDA- 2016/01/07 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2016/01/07 00:00 [pubmed]
PHST- 2016/01/07 00:01 [medline]
AID - 10.1039/c5tb02062j [doi]
PST - ppublish
SO  - J Mater Chem B. 2016 Jan 7;4(1):71-86. doi: 10.1039/c5tb02062j. Epub 2015 Nov 27.