PMID- 32263068
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 4
IP  - 10
DP  - 2016 Mar 14
TI  - An integrated nanoplatform for theranostics via multifunctional core-shell 
      ferrite nanocubes.
PG  - 1908-1914
LID - 10.1039/c5tb01910a [doi]
AB  - Magnetic core-shell ferrite nanocubes (MNCs) were prepared by a two-step 
      pyrolysis. The MNCs not only exhibit an excellent magnetothermal effect, but also 
      can be used as T(2) magnetic resonance (MR) imaging agents. To obtain their good 
      biocompatibility and targeting ability, MNCs were modified with poly(ethylene 
      glycol) (PEG) and hyaluronic acid (HA). To further construct an integrated 
      nanoplatform for theranostics, doxorubicin (DOX) was loaded onto the surface of 
      MNCs by pH and heat sensitive chemical bonding. Notably, the MNCs showed a great 
      stability and magnetothermal effect. Moreover, they showed negligible toxicity 
      and synergistic therapy in vitro. Meanwhile, their MR imaging in vivo was further 
      verified. A novel integrated nanoplatform facilitates excellent targeted MR 
      imaging guided synergism of magnetothermal and chemotherapy. The multifunctional 
      nanocubes will be capable of playing a vital role in future cancer therapy.
FAU - Wang, Li
AU  - Wang L
AD  - The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai 
      Municipal Education Committee Key Laboratory of Molecular Imaging Probes and 
      Sensors, Shanghai Normal University, Shanghai 200234, China. yanghong@shnu.edu.cn 
      shipingy@shnu.edu.cn.
FAU - Yan, Yuping
AU  - Yan Y
FAU - Wang, Min
AU  - Wang M
FAU - Yang, Hong
AU  - Yang H
FAU - Zhou, Zhiguo
AU  - Zhou Z
FAU - Peng, Chen
AU  - Peng C
FAU - Yang, Shiping
AU  - Yang S
LA  - eng
PT  - Journal Article
DEP - 20160223
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2016/03/14 00:00
MHDA- 2016/03/14 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2016/03/14 00:00 [pubmed]
PHST- 2016/03/14 00:01 [medline]
AID - 10.1039/c5tb01910a [doi]
PST - ppublish
SO  - J Mater Chem B. 2016 Mar 14;4(10):1908-1914. doi: 10.1039/c5tb01910a. Epub 2016 
      Feb 23.