PMID- 32263142
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 4
IP  - 28
DP  - 2016 Jul 28
TI  - Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of 
      silica nanoparticles doped by Mo(6)I(8)(4+) metal clusters.
PG  - 4839-4846
LID - 10.1039/c6tb00723f [doi]
AB  - Silica nanoparticles (SNPs) doped by hexanuclear molybdenum cluster complexes 
      [Mo(6)X(8)L(6)](n) (X = Cl, Br, or I; L = various inorganic or organic ligands) 
      have been recently suggested as materials with high potential for biomedical 
      applications due to both their outstanding photoluminescence properties and their 
      ability to efficiently generate singlet oxygen upon photoirradiation. However, no 
      studies were undertaken so far to prove this concept. Therefore, here we examined 
      the potential of photoluminescent SNPs doped by Mo(6)I(8)(4+) for applications 
      such as bioimaging and photodynamic therapy using the human epidermoid larynx 
      carcinoma (Hep-2) cell line as a model. Our results demonstrated both: (i) 
      significant luminescence from cells with internalised molybdenum cluster-doped 
      SNPs combined with the low cytotoxicity of particles in the darkness and (ii) 
      significant cytotoxicity of the particles upon photoirradiation. Thus, this 
      research provides strong experimental evidence for high potential of 
      molybdenum-cluster-doped materials in biomedical applications such as optical 
      bioimaging, biolabeling and photodynamic therapy.
FAU - Solovieva, Anastasiya O
AU  - Solovieva AO
AD  - Scientific Institute of Clinical and Experimental Lymphology, 2 Timakova st., 
      630060 Novosibirsk, Russian Federation.
FAU - Vorotnikov, Yuri A
AU  - Vorotnikov YA
FAU - Trifonova, Kristina E
AU  - Trifonova KE
FAU - Efremova, Olga A
AU  - Efremova OA
FAU - Krasilnikova, Anna A
AU  - Krasilnikova AA
FAU - Brylev, Konstantin A
AU  - Brylev KA
FAU - Vorontsova, Elena V
AU  - Vorontsova EV
FAU - Avrorov, Pavel A
AU  - Avrorov PA
FAU - Shestopalova, Lidiya V
AU  - Shestopalova LV
FAU - Poveshchenko, Alexander F
AU  - Poveshchenko AF
FAU - Mironov, Yuri V
AU  - Mironov YV
FAU - Shestopalov, Michael A
AU  - Shestopalov MA
LA  - eng
PT  - Journal Article
DEP - 20160627
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2016/07/28 00:00
MHDA- 2016/07/28 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2016/07/28 00:00 [pubmed]
PHST- 2016/07/28 00:01 [medline]
AID - 10.1039/c6tb00723f [doi]
PST - ppublish
SO  - J Mater Chem B. 2016 Jul 28;4(28):4839-4846. doi: 10.1039/c6tb00723f. Epub 2016 
      Jun 27.