PMID- 32263215
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 4
IP  - 3
DP  - 2016 Jan 21
TI  - Photoresponsive real time monitoring silicon quantum dots for regulated delivery 
      of anticancer drugs.
PG  - 521-528
LID - 10.1039/c5tb02045j [doi]
AB  - Recently, photoresponsive nanoparticles have been widely used to develop drug 
      delivery systems (DDSs) wherein light is used as an external stimulus to trigger 
      drug release in a spatially and temporally controlled fashion. Real time 
      monitoring DDSs are also gaining much interest due to their capability of 
      monitoring drug release in situ. In this context we designed a new 
      photoresponsive real time monitoring nanoparticle based on photoluminescent 
      silicon quantum dots (SiQDs) using the o-nitrobenzyl (ONB) derivative as a 
      phototrigger for the controlled release of anticancer drug chlorambucil (Cbl). 
      The strong fluorescence of SiQDs was initially quenched by ONB. Upon irradiation 
      ONB triggered the release of the drug switching on the fluorescence of SiQDs to 
      monitor the drug release. We reported a new and simple strategy to synthesise 
      amine functionalised silicon quantum dots and covalently conjugated phototrigger 
      ONB with caged anticancer drug Cbl onto it. Newly designed photoresponsive 
      theranostic ONBCbl-SiQDs performed three important functions: (i) nanocarriers 
      for drug delivery, (ii) controlled drug release under both one photon and 
      two-photon excitation, and (iii) photoswitchable fluorescent nanoparticles for 
      real-time monitoring of drug release based on the photoinduced electron transfer 
      (PET) process. In vitro biological studies revealed the efficient cellular 
      internalisation and cancer cell destruction ability of ONBCbl-SiQDs upon 
      photoirradiation. ONBCbl-SiQDs exhibit a successful example of combining multiple 
      functions into a single system for drug delivery systems.
FAU - Paul, Amrita
AU  - Paul A
AD  - Department of Chemistry, Indian Institute of Technology Kharagpur, 721302, West 
      Bengal, India. ndpradeep@chem.iitkgp.ernet.in.
FAU - Jana, Avijit
AU  - Jana A
FAU - Karthik, S
AU  - Karthik S
FAU - Bera, Manoranjan
AU  - Bera M
FAU - Zhao, Yanli
AU  - Zhao Y
FAU - Singh, N D Pradeep
AU  - Singh NDP
LA  - eng
PT  - Journal Article
DEP - 20151218
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2016/01/21 00:00
MHDA- 2016/01/21 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2016/01/21 00:00 [pubmed]
PHST- 2016/01/21 00:01 [medline]
AID - 10.1039/c5tb02045j [doi]
PST - ppublish
SO  - J Mater Chem B. 2016 Jan 21;4(3):521-528. doi: 10.1039/c5tb02045j. Epub 2015 Dec 
      18.