PMID- 32264626
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200408
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 5
IP  - 7
DP  - 2017 Feb 21
TI  - Stimuli-responsive delivery vehicles based on mesoporous silica nanoparticles: 
      recent advances and challenges.
PG  - 1339-1352
LID - 10.1039/c6tb03066a [doi]
AB  - In the past decade, stimuli-responsive drug delivery vehicles based on 
      surface-functionalized mesoporous silica nanoparticles (MSNs) have attracted 
      intense interest as a new type of drug carrier. These intelligent drug delivery 
      systems have been demonstrated to enable precise drug release into highly 
      specified targets and exhibit nearly "zero premature release" in systemic 
      circulation. It is expected that an in-depth understanding of the basic 
      mechanisms of the MSN-based stimuli-responsive drug delivery systems (DDSs) would 
      further contribute to this breakthrough field of nanomedicine. In this review, 
      the recent advances in the development of stimuli-responsive systems based on 
      MSNs are summarized and discussed, including single stimuli-responsive DDSs, dual 
      stimuli-responsive DDSs and multi stimuli-responsive DDSs. The challenges for 
      stimuli-responsive DDSs based on MSNs with regards to future translation into 
      clinical use are also simply discussed.
FAU - Zhu, Jianhua
AU  - Zhu J
AD  - Department of Pharmacy, Bengbu Medical College, Bengbu 233030, China.
FAU - Niu, Yimin
AU  - Niu Y
FAU - Li, Yang
AU  - Li Y
FAU - Gong, Yaxiang
AU  - Gong Y
FAU - Shi, Huihui
AU  - Shi H
FAU - Huo, Qiang
AU  - Huo Q
FAU - Liu, Yang
AU  - Liu Y
FAU - Xu, Qunwei
AU  - Xu Q
LA  - eng
PT  - Journal Article
DEP - 20170116
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
SB  - IM
EDAT- 2017/02/21 00:00
MHDA- 2017/02/21 00:01
CRDT- 2020/04/09 06:00
PHST- 2020/04/09 06:00 [entrez]
PHST- 2017/02/21 00:00 [pubmed]
PHST- 2017/02/21 00:01 [medline]
AID - 10.1039/c6tb03066a [doi]
PST - ppublish
SO  - J Mater Chem B. 2017 Feb 21;5(7):1339-1352. doi: 10.1039/c6tb03066a. Epub 2017 
      Jan 16.