PMID- 32264927 OWN - NLM STAT- MEDLINE DCOM- 20210111 LR - 20210111 IS - 1478-6362 (Electronic) IS - 1478-6354 (Print) IS - 1478-6354 (Linking) VI - 22 IP - 1 DP - 2020 Apr 7 TI - Serum interleukin-16 significantly correlates with the Vasculitis Damage Index in antineutrophil cytoplasmic antibody-associated vasculitis. PG - 73 LID - 10.1186/s13075-020-02172-5 [doi] LID - 73 AB - BACKGROUND: Interleukin (IL)-16 is a T cell chemoattractant produced by peripheral mononuclear cells. We investigated whether IL-16 plays a pro- or an anti-inflammatory role in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Furthermore, we investigated whether the level of IL-16 could predict the activity and extent of organ damage in AAV based on AAV-specific indices. METHODS: Seventy-eight patients with AAV from a prospective observational cohort were included in this analysis. Blood sampling and clinical assessments, including the Birmingham Vasculitis Activity Score (BVAS), Five-Factor Score (FFS), Short Form 36-item Health Survey (SF-36), and Vasculitis Damage Index (VDI), were performed, and laboratory data were collected. Serum IL-16 was measured from stored sera. RESULTS: The median age was 62.0 years, and 27 patients were male. The median serum IL-16 concentration was 84.1 pg/dL, and the median BVAS, FFS, VDI, and SF-36 scores were 7.0, 1.0, 3.0, and 48.0, respectively. Among the AAV-related indices, the serum IL-16 concentration was correlated with VDI (R(2) = 0.306, P = 0.006), but not with BVAS (R(2) = 0.024, P = 0.834), FFS (R(2) = - 0.069, P = 0.550), or SF-36 (R(2) = - 0.015, P = 0.898). The serum IL-16 concentration also did not correlate with either the erythrocyte sedimentation rate or the C-reactive protein concentration. Per our analysis based on organ involvement, only patients with ear, nose, and throat manifestations had higher serum IL-16 concentrations relative to those with other conditions (P = 0.030). CONCLUSIONS: This was the first study to elucidate the clinical implication of serum IL-16 in patients with AAV. We found that the serum IL-16 level may reflect the cross-sectional VDI scores among AAV-specific indices. Future studies with larger numbers of patients and serial measurements could provide more reliable data on the clinical implications of serum IL-16 in AAV. FAU - Yoon, Taejun AU - Yoon T AD - Department of Medical Science, BK21 Plus Project, College of Medicine, Yonsei University, Seoul, Republic of Korea. FAU - Pyo, Jung Yoon AU - Pyo JY AD - Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Ahn, Sung Soo AU - Ahn SS AD - Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Song, Jason Jungsik AU - Song JJ AD - Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. AD - Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul, Republic of Korea. FAU - Park, Yong-Beom AU - Park YB AD - Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. AD - Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul, Republic of Korea. FAU - Lee, Sang-Won AU - Lee SW AUID- ORCID: 0000-0002-8038-3341 AD - Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. sangwonlee@yuhs.ac. AD - Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul, Republic of Korea. sangwonlee@yuhs.ac. LA - eng GR - HI14C1324/Korea Health Industry Development Institute/International GR - 2017R1D1A1B03029050/Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education/International PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20200407 PL - England TA - Arthritis Res Ther JT - Arthritis research & therapy JID - 101154438 RN - 0 (Interleukin-16) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*blood/*diagnosis MH - Ear/blood supply MH - Female MH - Humans MH - Interleukin-16/*blood MH - Male MH - Middle Aged MH - Nose/blood supply MH - Pharynx/blood supply MH - Prospective Studies MH - *Severity of Illness Index PMC - PMC7140543 OTO - NOTNLM OT - Activity OT - Antineutrophil cytoplasmic antibody-associated vasculitis OT - Reflect OT - Serum IL-16 OT - Vasculitis damage COIS- The authors declare that they have no competing interests. EDAT- 2020/04/09 06:00 MHDA- 2021/01/12 06:00 PMCR- 2020/04/07 CRDT- 2020/04/09 06:00 PHST- 2020/02/07 00:00 [received] PHST- 2020/03/30 00:00 [accepted] PHST- 2020/04/09 06:00 [entrez] PHST- 2020/04/09 06:00 [pubmed] PHST- 2021/01/12 06:00 [medline] PHST- 2020/04/07 00:00 [pmc-release] AID - 10.1186/s13075-020-02172-5 [pii] AID - 2172 [pii] AID - 10.1186/s13075-020-02172-5 [doi] PST - epublish SO - Arthritis Res Ther. 2020 Apr 7;22(1):73. doi: 10.1186/s13075-020-02172-5.