PMID- 32265646
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - Repeated Paced Mating Increases the Survival of New Neurons in the Accessory 
      Olfactory Bulb.
PG  - 249
LID - 10.3389/fnins.2020.00249 [doi]
LID - 249
AB  - In female rats, the first sexual experience under paced mating conditions 
      increases the number of newborn cells that migrate into the granular layer of the 
      accessory olfactory bulb (AOB). Repeated paced mating has a potentiating effect 
      on the number of new neurons that migrate to the AOB compared with a single 
      session 15 days after paced mating. On the other hand, one paced mating session 
      does no increases the survival of new cells 45 days after mating. In the present 
      study, we evaluated if four paced mating sessions could increase the survival of 
      new neurons in the AOB and main olfactory bulb (MOB) 45 days after females mated. 
      Sexually naive female rats were ovariectomized, hormonally supplemented and 
      randomly assigned to one of five groups: (1) Control, no sexual contact (C); (2) 
      Four sessions in which females were exposed, without mating, to a sexually 
      experience male rat (SE); (3) One session of paced mating (PM1); (4) Four 
      sessions of paced mating (PM4); and (5) Four sessions of non-paced mating (NPM4). 
      In the first behavioral test, females received the DNA synthesis marker 
      5-bromo-2'deoxyuridine and were euthanized 45 days later. Our data showed that 
      the number of new cells that survived in the mitral cell layer of the AOB 
      decreased when females were exposed to a sexually active male, in comparison to 
      females that mated once pacing the sexual interaction. Repeated sexual behavior 
      in pacing conditions did not increase the survival of new cells in other layers 
      of the MOB and AOB. However, a significant increase in the percentage of new 
      neurons in the granular and glomerular layers of the AOB and granular layer of 
      the MOB was observed in females that mated in four sessions pacing the sexual 
      interaction. In the group that paced the sexual interaction for one session, a 
      significant increase in the percentage of neurons was observed in the glomerular 
      layer of the AOB. Our data suggest that repeated paced mating increases the 
      percentage of new neurons that survive in the olfactory bulb of female rats.
CI  - Copyright (c) 2020 Portillo, Ortiz and Paredes.
FAU - Portillo, Wendy
AU  - Portillo W
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico (UNAM), 
      sQueretaro, Mexico.
FAU - Ortiz, Georgina
AU  - Ortiz G
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico (UNAM), 
      sQueretaro, Mexico.
FAU - Paredes, Raul G
AU  - Paredes RG
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico (UNAM), 
      sQueretaro, Mexico.
AD  - Escuela Nacional de Estudios Superiores, Unidad Juriquilla Universidad Nacional 
      Autonoma de Mexico (UNAM), Queretaro, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20200324
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7105896
OTO - NOTNLM
OT  - cell survival
OT  - neuronal differentiation
OT  - olfactory bulb
OT  - paced mating
OT  - sexual experience
EDAT- 2020/04/09 06:00
MHDA- 2020/04/09 06:01
PMCR- 2020/01/01
CRDT- 2020/04/09 06:00
PHST- 2019/10/14 00:00 [received]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2020/04/09 06:00 [entrez]
PHST- 2020/04/09 06:00 [pubmed]
PHST- 2020/04/09 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.00249 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Mar 24;14:249. doi: 10.3389/fnins.2020.00249. eCollection 
      2020.