PMID- 32266320
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2391-5463 (Print)
IS  - 2391-5463 (Electronic)
VI  - 15
DP  - 2020
TI  - LncRNA LINC00152 Promotes Laryngeal Cancer Progression by Sponging MiR-613.
PG  - 240-248
LID - 10.1515/med-2020-0035 [doi]
AB  - BACKGROUND: Long noncoding RNA (lncRNA) LINC00152 (CYTOR) has been reported to be 
      upregulated and to serve as a diagnostic biomarker in multiple types of cancers, 
      including laryngeal squamous cell cancer (LSCC). However, the functional role and 
      molecular mechanisms of LINC00152 in LSCC progression need to be further 
      investigated. METHODS: LINC00152 levels in LSCC and adjacent normal tissues were 
      measured by quantitative real-time polymerase chain reaction (qRT-PCR). Gene 
      knockdown of LINC00152 was achieved in LSCC cells by use of small interfering RNA 
      (siRNA). Cell proliferation, apoptosis, migration and invasion were examined by a 
      series of methods. The micoRNA (miRNA) interaction with LINC00152 was screened by 
      starBase v2.0 and confirmed by luciferase reporter activity. RESULTS: LINC00152 
      levels in LSCC tissues were significantly higher than those in adjacent normal 
      tissue, and patients with lymph node metastasis or an advanced clinical stage 
      displayed higher LINC00152 expression. Moreover, siRNA-mediated LINC00152 
      knockdown significantly inhibited the proliferation, migration and invasion of 
      LSCC cells and induced apoptosis in those cells. Mechanistically, LINC00152 
      functioned as a competing endogenous RNA (ceRNA) sponging miR-613. The inhibitory 
      effect of LINC00152 knockdown on malignant behavior was abrogated by inhibiting 
      miR-613. CONCLUSION: LINC00152 exerts an oncogenic effect on the tumorigenesis of 
      LSCC by sponging miR-613 and may serve as a potential target for treating LSCC.
CI  - (c) 2020 Xuesong Zheng et al., published by De Gruyter.
FAU - Zheng, Xuesong
AU  - Zheng X
AD  - Department of Otolaryngology Head and Neck surgery, the Affiliated Hospital of 
      Beihua University, Jilin 132001, P.R. China.
FAU - Dong, Su
AU  - Dong S
AD  - Departments of Anesthesia, the First Hospital of Jilin University, Changchun 
      130021, P.R. China.
FAU - Sun, Lele
AU  - Sun L
AD  - Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 
      130021, P.R. China.
FAU - Xu, Jialu
AU  - Xu J
AD  - Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 
      130021, P.R. China.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 
      130021, P.R. China.
FAU - Hao, Rui
AU  - Hao R
AD  - Department of Infection, The Affiliated Hospital of Beihua University, Jilin 
      132001, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200326
PL  - Poland
TA  - Open Med (Wars)
JT  - Open medicine (Warsaw, Poland)
JID - 101672167
PMC - PMC7126196
OTO - NOTNLM
OT  - LINC00152
OT  - laryngeal squamous cell cancer
OT  - long noncoding RNA
OT  - miR-613
COIS- Conflict of interest: Authors state no conflict of interest.
EDAT- 2020/04/09 06:00
MHDA- 2020/04/09 06:01
PMCR- 2020/03/26
CRDT- 2020/04/09 06:00
PHST- 2019/10/20 00:00 [received]
PHST- 2020/01/29 00:00 [accepted]
PHST- 2020/04/09 06:00 [entrez]
PHST- 2020/04/09 06:00 [pubmed]
PHST- 2020/04/09 06:01 [medline]
PHST- 2020/03/26 00:00 [pmc-release]
AID - med-2020-0035 [pii]
AID - 10.1515/med-2020-0035 [doi]
PST - epublish
SO  - Open Med (Wars). 2020 Mar 26;15:240-248. doi: 10.1515/med-2020-0035. eCollection 
      2020.