PMID- 32270335
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 125
IP  - 10
DP  - 2020 Oct
TI  - Outpatient Yttrium-90 microsphere radioembolization: assessment of radiation 
      safety and quantification of post-treatment adverse events causing 
      hospitalization.
PG  - 971-980
LID - 10.1007/s11547-020-01180-4 [doi]
AB  - PURPOSE: Quantification of post-interventional adverse events of outpatient SIRT 
      leading to hospitalization and quantification of radiation exposure. MATERIALS 
      AND METHODS: In this single-center, retrospective cohort study, we reviewed 212 
      patients treated with SIRT ((90)Y-microspheres) for primary and secondary liver 
      malignancies. We searched for adverse events (AEs) and serious adverse events 
      (SAEs), defined as AE's causing hospitalization. Additionally, radiation exposure 
      was measured in 36 patients. RESULTS: Seven patients had an SAE (3.3%), four 
      patients had AE without readmission/hospitalization (1.9%) and 201 patients had 
      no complications (94.8%). The mean ambient dose rate at 1 m distance from the 
      source after administration of (90)Y-microspheres was 1.88 microSv/h +/- 0.74 (+/- SD) 
      with a range from 4.3 to 0.2 microSv/h. CONCLUSION: Outpatient radioembolization with 
      (90)Y-microspheres is safe and requires hospitalization only in a very small 
      number of patients. The mean dose rate was low and met the national conditions 
      for outpatient treatment (< 5 microSv/h).
FAU - Aberle, Susanne
AU  - Aberle S
AD  - Department of Oncology, University Hospital Zurich, Zurich, Switzerland.
FAU - Kenkel, David
AU  - Kenkel D
AD  - Department of Diagnostic and Interventional Radiology, University Hospital 
      Zurich, Ramistrasse 100, 8091, Zurich, Switzerland. david.kenkel@usz.ch.
FAU - Becker, Anton S
AU  - Becker AS
AD  - Department of Diagnostic and Interventional Radiology, University Hospital 
      Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
FAU - Puippe, Gilbert
AU  - Puippe G
AD  - Department of Diagnostic and Interventional Radiology, University Hospital 
      Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
FAU - Burger, Irene
AU  - Burger I
AD  - Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
FAU - Schaefer, Niklaus
AU  - Schaefer N
AD  - Department of Nuclear Medicine, University Hospital Lausanne, Lausanne, 
      Switzerland.
FAU - Pfammatter, Thomas
AU  - Pfammatter T
AD  - Department of Diagnostic and Interventional Radiology, University Hospital 
      Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20200408
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
RN  - 0 (Yttrium Radioisotopes)
RN  - 1K8M7UR6O1 (Yttrium-90)
SB  - IM
MH  - *Ambulatory Care
MH  - Angiography
MH  - Embolization, Therapeutic/adverse effects/*methods
MH  - Female
MH  - *Hospitalization/statistics & numerical data
MH  - Humans
MH  - Liver Neoplasms/blood supply/secondary/*therapy
MH  - Male
MH  - *Microspheres
MH  - Middle Aged
MH  - Outpatients
MH  - Radiation Exposure/analysis
MH  - Radiation Pneumonitis/prevention & control
MH  - Retrospective Studies
MH  - Single Photon Emission Computed Tomography Computed Tomography
MH  - Yttrium Radioisotopes/*administration & dosage/adverse effects
OTO - NOTNLM
OT  - Outpatient
OT  - Patient safety
OT  - Radiation exposure
OT  - Radiation protection
OT  - SAE
OT  - SIRT
EDAT- 2020/04/10 06:00
MHDA- 2020/09/10 06:00
CRDT- 2020/04/10 06:00
PHST- 2019/02/05 00:00 [received]
PHST- 2020/03/23 00:00 [accepted]
PHST- 2020/04/10 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2020/04/10 06:00 [entrez]
AID - 10.1007/s11547-020-01180-4 [pii]
AID - 10.1007/s11547-020-01180-4 [doi]
PST - ppublish
SO  - Radiol Med. 2020 Oct;125(10):971-980. doi: 10.1007/s11547-020-01180-4. Epub 2020 
      Apr 8.