PMID- 32272189
OWN - NLM
STAT- MEDLINE
DCOM- 20200731
LR  - 20200731
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 163
DP  - 2020 May
TI  - Changes in mortality rates and ratios in people with pharmacologically treated 
      type 2 diabetes mellitus between 2001 and 2016 in Hungary.
PG  - 108134
LID - S0168-8227(20)30384-3 [pii]
LID - 10.1016/j.diabres.2020.108134 [doi]
AB  - AIMS: Type 2 diabetes mellitus (T2DM) is associated with a higher risk of 
      all-cause mortality; however, detailed analyses of subgroups are rare. In this 
      study we analyzed the changes of age- and gender-specific all-cause mortality 
      rates and ratios in T2DM subjects (aged > 40 years) in Hungary between 2001 and 
      2016. METHODS: We used the central database of the National Institute of Health 
      Insurance Fund. All-cause mortality rates in patients with T2DM and ratios 
      (T2DM/non-T2DM) were determined in males/females and in different age-groups. 
      Age-adjusted values were used for standardized mortality rates. RESULTS: Among 
      pharmacologically treated T2DM subjects we found 117,700 and 329,845 males, 
      232,143 and 391,382 females in 2001 and 2016, respectively. Standardized 
      all-cause mortality rate was higher in males than in females in 2001 
      (4540/100,000 vs. 3365/100,000) which decreased to 4125/100,000 in males (total 
      change: -11.8%, p < 0.0001) and to 2977/100,000 in females (total change: -9.2%; 
      p = 0.0558) in 2016. We found a significant increase (8.35%; p = 0.0272) in 
      standardized all-cause mortality ratios between 2001 and 2016 which was higher in 
      males (11.44%; p = 0.0096) than in females (2.78%; p = 0.3288). We observed the 
      most pronounced increase in younger age-groups (age 41-60 years) in both genders 
      (change varied from 54.2% to 101.8%; p < 0.05) which was due to distinct 
      tendencies in changes of mortality curves. CONCLUSIONS: Pharmacologically treated 
      T2DM subjects in lower age-groups (41-60 years) had the highest increase in 
      all-cause mortality ratios between 2001 and 2016 in Hungary. These data indicate 
      that relatively younger patients with T2DM need special attention for improving 
      long-term outcomes.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Jermendy, Gyorgy
AU  - Jermendy G
AD  - Bajcsy-Zsilinszky Hospital, Maglodi ut 89-91, 1106 Budapest, Hungary. Electronic 
      address: gyjermendy@bajcsy.hu.
FAU - Kiss, Zoltan
AU  - Kiss Z
AD  - University of Pecs, Faculty of Medicine, 2(nd) Department of Medicine, 
      Nephrological and Diabetes Center, Pacsirta ut 1, 7624 Pecs, Hungary. Electronic 
      address: kiss.zoltan2@pte.hu.
FAU - Rokszin, Gyorgy
AU  - Rokszin G
AD  - RxTarget Ltd., Bacso Nandor ut 10, 5000 Szolnok, Hungary. Electronic address: 
      rokszin.gyorgy@rxtarget.hu.
FAU - Fabian, Ibolya
AU  - Fabian I
AD  - RxTarget Ltd., Bacso Nandor ut 10, 5000 Szolnok, Hungary. Electronic address: 
      fabian.ibolya@rxtarget.hu.
FAU - Wittmann, Istvan
AU  - Wittmann I
AD  - University of Pecs, Faculty of Medicine, 2(nd) Department of Medicine, 
      Nephrological and Diabetes Center, Pacsirta ut 1, 7624 Pecs, Hungary. Electronic 
      address: istvan.wittmann@aok.pte.hu.
FAU - Kempler, Peter
AU  - Kempler P
AD  - Semmelweis University, Faculty of Medicine, 1(st) Department of Medicine, Koranyi 
      Sandor ut 2, 1083 Budapest, Hungary. Electronic address: 
      kempler.peter@med.semmelweis-univ.hu.
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20200406
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Adult
MH  - Aged
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/*drug therapy/mortality
MH  - Female
MH  - History, 21st Century
MH  - Humans
MH  - Hungary
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Database-analysis
OT  - Mortality rate
OT  - Mortality ratio
OT  - Nationwide data
OT  - Type 2 diabetes mellitus
EDAT- 2020/04/10 06:00
MHDA- 2020/08/01 06:00
CRDT- 2020/04/10 06:00
PHST- 2020/01/20 00:00 [received]
PHST- 2020/03/18 00:00 [revised]
PHST- 2020/03/26 00:00 [accepted]
PHST- 2020/04/10 06:00 [pubmed]
PHST- 2020/08/01 06:00 [medline]
PHST- 2020/04/10 06:00 [entrez]
AID - S0168-8227(20)30384-3 [pii]
AID - 10.1016/j.diabres.2020.108134 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2020 May;163:108134. doi: 10.1016/j.diabres.2020.108134. 
      Epub 2020 Apr 6.