PMID- 32272268 OWN - NLM STAT- MEDLINE DCOM- 20200828 LR - 20221207 IS - 1878-8769 (Electronic) IS - 1878-8750 (Linking) VI - 138 DP - 2020 Jun TI - Custom-Made Porous Hydroxyapatite Cranioplasty in Patients with Tumor Versus Traumatic Brain Injury: A Single-Center Case Series. PG - e922-e929 LID - S1878-8750(20)30615-X [pii] LID - 10.1016/j.wneu.2020.03.144 [doi] AB - BACKGROUND: Cranioplasty is a common neurosurgical procedure with the goal of restoring skull integrity. Custom-made porous hydroxyapatite prostheses have long been used for cranial reconstruction in patients with traumatic brain injury. We present a large consecutive series of 2 groups of patients undergoing cranioplasty with hydroxyapatite custom bone and compare the adverse events (AEs) between the 2 groups. METHODS: We examined a series of consecutive patients who underwent cranioplasty using custom-made porous hydroxyapatite implants following tumor resection and traumatic brain injury at a single center between March 2003 and May 2018. The implants were designed and produced according to the surgeon's specifications and based on the patient's computed tomography scan data obtained through a standardized protocol. AEs were recorded. RESULTS: Information on 38 patients with tumor and 39 patients with traumatic brain injury was collected and analyzed. A significant difference in the timing of surgery was found between the 2 groups; single-stage surgery was performed in 84% of patients in the tumor versus 8% of those in the traumatic brain injury group (P < 0.0001). The rate of AEs was not significantly different between the 2 groups (P = 0.4309) and was not related to the timing of surgery. CONCLUSIONS: Custom-made hydroxyapatite cranioplasty is a solution for cranial reconstruction in patients with cranial tumors. The low incidence of AEs in a consecutive series of patients with either trauma or tumors demonstrates that these prostheses represent a safe solution independent of the characteristics of cases. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Rossini, Zefferino AU - Rossini Z AD - Department of Neurosurgery, Humanitas Clinical and Research Center - IRCCS, Rozzano (MI), Italy. Electronic address: zefferino.rossini@humanitas.it. FAU - Franzini, Andrea AU - Franzini A AD - Department of Neurosurgery, Humanitas Clinical and Research Center - IRCCS, Rozzano (MI), Italy. FAU - Zaed, Ismail AU - Zaed I AD - Department of Neurosurgery, Humanitas Clinical and Research Center - IRCCS, Rozzano (MI), Italy. FAU - Zingaretti, Nicola AU - Zingaretti N AD - Department of Plastic Reconstructive Surgery, Azienda Ospedaliera Universitaria "S. Maria della Misericordia", Udine, Italy. FAU - Nicolosi, Federico AU - Nicolosi F AD - Department of Neurosurgery, Humanitas Clinical and Research Center - IRCCS, Rozzano (MI), Italy. FAU - Zanotti, Bruno AU - Zanotti B AD - Department of Neurosurgery, Ospedale Carlo Poma, Mantova, Italy. LA - eng PT - Journal Article DEP - 20200406 PL - United States TA - World Neurosurg JT - World neurosurgery JID - 101528275 RN - 91D9GV0Z28 (Durapatite) SB - IM MH - Adult MH - Brain Injuries, Traumatic/*surgery MH - Brain Neoplasms/*surgery MH - Durapatite MH - Female MH - Humans MH - Male MH - Middle Aged MH - Neurosurgical Procedures/*methods MH - Porosity MH - Plastic Surgery Procedures/instrumentation/*methods MH - Treatment Outcome OTO - NOTNLM OT - Brain tumor OT - Cranioplasty OT - Custom-made hydroxyapatite cranioplasty OT - Skull tumor OT - Traumatic brain injury EDAT- 2020/04/10 06:00 MHDA- 2020/08/29 06:00 CRDT- 2020/04/10 06:00 PHST- 2020/02/05 00:00 [received] PHST- 2020/03/23 00:00 [revised] PHST- 2020/03/24 00:00 [accepted] PHST- 2020/04/10 06:00 [pubmed] PHST- 2020/08/29 06:00 [medline] PHST- 2020/04/10 06:00 [entrez] AID - S1878-8750(20)30615-X [pii] AID - 10.1016/j.wneu.2020.03.144 [doi] PST - ppublish SO - World Neurosurg. 2020 Jun;138:e922-e929. doi: 10.1016/j.wneu.2020.03.144. Epub 2020 Apr 6.