PMID- 32272333
OWN - NLM
STAT- MEDLINE
DCOM- 20210226
LR  - 20210313
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Print)
IS  - 1059-1311 (Linking)
VI  - 78
DP  - 2020 May
TI  - Controversies on the network theory of epilepsy: Debates held during the ICTALS 
      2019 conference.
PG  - 78-85
LID - S1059-1311(20)30085-6 [pii]
LID - 10.1016/j.seizure.2020.03.010 [doi]
AB  - Debates on six controversial topics on the network theory of epilepsy were held 
      during two debate sessions, as part of the International Conference for 
      Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the 
      University of Exeter, UK, September 2-5 2019. The debate topics were (1) From 
      pathologic to physiologic: is the epileptic network part of an existing 
      large-scale brain network? (2) Are micro scale recordings pertinent for defining 
      the epileptic network? (3) From seconds to years: do we need all temporal scales 
      to define an epileptic network? (4) Is it necessary to fully define the epileptic 
      network to control it? (5) Is controlling seizures sufficient to control the 
      epileptic network? (6) Does the epileptic network want to be controlled? This 
      article, written by the organizing committee for the debate sessions and the 
      debaters, summarizes the arguments presented during the debates on these six 
      topics.
CI  - Copyright (c) 2020 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Zaveri, Hitten P
AU  - Zaveri HP
AD  - Department of Neurology, Yale University, New Haven, CT 06520, USA.
FAU - Schelter, Bjorn
AU  - Schelter B
AD  - Institute for Complex Systems and Mathematical Biology, University of Aberdeen, 
      Aberdeen AB24 3UE, UK.
FAU - Schevon, Catherine A
AU  - Schevon CA
AD  - Department of Neurology, Columbia University, New York, NY, USA.
FAU - Jiruska, Premysl
AU  - Jiruska P
AD  - Department of Physiology, Second Faculty of Medicine, Charles University, Prague, 
      Czech Republic.
FAU - Jefferys, John G R
AU  - Jefferys JGR
AD  - Department of Physiology, Second Faculty of Medicine, Charles University, Prague, 
      Czech Republic; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, 
      UK.
FAU - Worrell, Gregory
AU  - Worrell G
AD  - Mayo Systems Electrophysiology Laboratory, Departments of Neurology and 
      Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Schulze-Bonhage, Andreas
AU  - Schulze-Bonhage A
AD  - Epilepsy Center, University Medical Center Freiburg, Freiburg, Germany.
FAU - Joshi, Rasesh B
AU  - Joshi RB
AD  - Department of Neurobiology and Anatomy, Wake Forest School of Medicine, 
      Winston-Salem, NC, USA.
FAU - Jirsa, Viktor
AU  - Jirsa V
AD  - Institut de Neurosciences des Systemes, Aix Marseille University, Marseille, 
      France.
FAU - Goodfellow, Marc
AU  - Goodfellow M
AD  - Living Systems Institute, University of Exeter, Exeter, UK; Wellcome Trust Centre 
      for Biomedical Modelling and Analysis, University of Exeter, Exeter, UK; EPSRC 
      Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK.
FAU - Meisel, Christian
AU  - Meisel C
AD  - Department of Neurology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 
      02115, USA; Department of Neurology, University Clinic Carl Gustav Carus, 
      Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Lehnertz, Klaus
AU  - Lehnertz K
AD  - Department of Epileptology, University of Bonn, Venusberg Campus 1, 53127 Bonn, 
      Germany; Interdisciplinary Center for Complex Systems, University of Bonn, 
      Bruhler Str. 7, 53175 Bonn, Germany. Electronic address: 
      Klaus.Lehnertz@ukbonn.de.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - R01 NS109062/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20200319
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
SB  - IM
MH  - Congresses as Topic
MH  - Epilepsy/diagnosis/drug therapy/*physiopathology
MH  - Humans
MH  - Nerve Net/drug effects/*physiopathology
PMC - PMC7952007
MID - NIHMS1673775
OTO - NOTNLM
OT  - Edges
OT  - Epileptic network
OT  - Epileptogenesis
OT  - Ictogenesis
OT  - Nodes
OT  - Seizure control
COIS- Declaration of Competing Interest HZ has a grant award from the NIH (USA) on 
      network analysis for epilepsy surgery, and is named as an inventor on patents for 
      monitoring and modulating human brain activity.
EDAT- 2020/04/10 06:00
MHDA- 2021/02/27 06:00
PMCR- 2021/03/11
CRDT- 2020/04/10 06:00
PHST- 2020/01/31 00:00 [received]
PHST- 2020/03/13 00:00 [revised]
PHST- 2020/03/15 00:00 [accepted]
PHST- 2020/04/10 06:00 [pubmed]
PHST- 2021/02/27 06:00 [medline]
PHST- 2020/04/10 06:00 [entrez]
PHST- 2021/03/11 00:00 [pmc-release]
AID - S1059-1311(20)30085-6 [pii]
AID - 10.1016/j.seizure.2020.03.010 [doi]
PST - ppublish
SO  - Seizure. 2020 May;78:78-85. doi: 10.1016/j.seizure.2020.03.010. Epub 2020 Mar 19.