PMID- 32273014
OWN - NLM
STAT- MEDLINE
DCOM- 20201124
LR  - 20201124
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 243
DP  - 2020 Apr
TI  - Pathogenesis and tissue tropism of natural field recombinants of infectious 
      laryngotracheitis virus.
PG  - 108635
LID - S0378-1135(19)31177-0 [pii]
LID - 10.1016/j.vetmic.2020.108635 [doi]
AB  - Infectious laryngotracheitis virus (ILTV) is an economically significant 
      respiratory pathogen of poultry. Novel recombinant strains of ILTV have emerged 
      in Australia during the last decade and currently class 9 (CL9) and class 10 
      (CL10) ILTV are the most prevalent circulating strains. This study conducted a 
      comprehensive investigation of the pathogenesis of these two viral strains. 
      Commercial broiler and specific pathogen free (SPF) chickens were inoculated with 
      varying doses of CL9 or CL10 ILTV and subsequently evaluated for clinical and 
      pathological signs of infection. While no difference in the levels of acute viral 
      replication were observed across the different challenge doses, the severity of 
      clinical signs, tracheal pathology and mortality were dose dependent. Both 
      strains of virus persisted in the respiratory tract for up to 14 days post 
      inoculation (dpi) and could be detected in the lung and feathers with sporadic 
      detection in the liver, spleen or bursa. Given the prevalence of CL9 and CL10 in 
      Australian poultry flocks, this study provides an important foundation for the 
      development of diagnostic and therapeutic approaches for the detection and 
      prevention of ILTV.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Thilakarathne, Dulari S
AU  - Thilakarathne DS
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 
      Victoria, 3010, Australia. Electronic address: 
      dthilakarath@student.unimelb.edu.au.
FAU - Noormohammadi, Amir H
AU  - Noormohammadi AH
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, 
      Victoria, 3030, Australia.
FAU - Browning, Glenn F
AU  - Browning GF
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 
      Victoria, 3010, Australia.
FAU - Quinteros, Jose A
AU  - Quinteros JA
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 
      Victoria, 3010, Australia.
FAU - Underwood, Gregory J
AU  - Underwood GJ
AD  - Bioproperties Proprietary Limited, 36 Charter Street, Ringwood, Victoria, 3134, 
      Australia.
FAU - Hartley, Carol A
AU  - Hartley CA
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 
      Victoria, 3010, Australia.
FAU - Coppo, Mauricio Jc
AU  - Coppo MJ
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 
      Victoria, 3010, Australia.
FAU - Devlin, Joanne M
AU  - Devlin JM
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 
      Victoria, 3010, Australia.
FAU - Diaz-Mendez, Andres
AU  - Diaz-Mendez A
AD  - Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of 
      Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 
      Victoria, 3010, Australia.
LA  - eng
PT  - Journal Article
DEP - 20200304
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Australia
MH  - Chickens/*virology
MH  - Feathers/virology
MH  - Genotype
MH  - Herpesviridae Infections/*veterinary
MH  - Herpesvirus 1, Gallid/genetics/*pathogenicity
MH  - Lung/virology
MH  - Poultry Diseases/*virology
MH  - Reassortant Viruses/pathogenicity
MH  - Specific Pathogen-Free Organisms
MH  - *Viral Tropism
MH  - Virus Replication
OTO - NOTNLM
OT  - ILTV
OT  - Natural field recombinants
OT  - Pathogenesis
OT  - Tissue tropism
COIS- Declaration of Competing Interest The authors have declared that they have no 
      competing interests.
EDAT- 2020/04/11 06:00
MHDA- 2020/11/25 06:00
CRDT- 2020/04/11 06:00
PHST- 2019/10/05 00:00 [received]
PHST- 2020/02/28 00:00 [revised]
PHST- 2020/03/03 00:00 [accepted]
PHST- 2020/04/11 06:00 [entrez]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2020/11/25 06:00 [medline]
AID - S0378-1135(19)31177-0 [pii]
AID - 10.1016/j.vetmic.2020.108635 [doi]
PST - ppublish
SO  - Vet Microbiol. 2020 Apr;243:108635. doi: 10.1016/j.vetmic.2020.108635. Epub 2020 
      Mar 4.