PMID- 32273043
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1715-3360 (Electronic)
IS  - 0008-4182 (Linking)
VI  - 55
IP  - 4
DP  - 2020 Aug
TI  - Alterations of the foveal central bouquet associated with cystoid macular edema.
PG  - 301-309
LID - S0008-4182(19)31301-8 [pii]
LID - 10.1016/j.jcjo.2020.01.013 [doi]
AB  - OBJECTIVE: The central bouquet (CB) of the fovea comprises a dense array of cone 
      photoreceptors intertwined with Muller cells. The aim of this investigation was 
      to study visual outcomes and structural alterations in the foveal CB associated 
      with cystoid macular edema (CME) of different etiologies. DESIGN: Retrospective 
      case series. PARTICIPANTS AND METHODS: This study analyzed eyes with various 
      etiologies of CME, including diabetic macular edema, central retinal vein 
      occlusion (CRVO), pseudophakic or Irvine-Gass (IG) syndrome, uveitis, and 
      retinitis pigmentosa using spectral-domain optical coherence tomography (SD-OCT). 
      SD-OCT was used to classify the CB alterations as either (1) thickened 
      hyper-reflectivity associated with indistinct ellipsoid zone (EZ), or (2) 
      subretinal fluid with intact EZ. Comparisons were made using the Students t test 
      and Fisher's exact test. RESULTS: The total cohort consisted of 61 eyes from 61 
      patients with various etiologies of CME. CB alterations were observed in 91% of 
      uveitis eyes, 82% of CRVO eyes and 50% of IG eyes. Presence of CB alteration 
      correlated with greater central macular thickness (p = 0.0020), horizontal extent 
      of edema (p = 0.0042), and worse baseline visual acuity (p = 0.0195). Type 2 CB 
      alterations were associated with worse logMAR vision compared with type 1 at 
      baseline and final examinations (p = 0.0002, p = 0.0470). CONCLUSIONS: CB 
      alterations were noted in the majority of eyes with CME from CRVO, uveitis, and 
      IG. The association observed between CB alterations and central macular thickness 
      suggests that these alterations may develop as a result of mechanical stress of 
      Muller cells on the CB.
CI  - Published by Elsevier Inc.
FAU - Lenis, Tamara L
AU  - Lenis TL
AD  - Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.
FAU - Au, Adrian
AU  - Au A
AD  - Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.
FAU - Hou, Kirk
AU  - Hou K
AD  - Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.
FAU - Govetto, Andrea
AU  - Govetto A
AD  - Department of Ophthalmology, Fatebenefratelli-Oftalmico Hospital, 
      ASST-Fatebenefratelli-Sacco, Milan, Italy.
FAU - Sarraf, David
AU  - Sarraf D
AD  - Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA; 
      Greater Los Angeles VA Healthcare Center, Los Angeles, CA. Electronic address: 
      dsarraf@ucla.edu.
LA  - eng
PT  - Journal Article
DEP - 20200407
PL  - England
TA  - Can J Ophthalmol
JT  - Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
JID - 0045312
SB  - IM
MH  - *Diabetic Retinopathy
MH  - Fovea Centralis
MH  - Humans
MH  - *Macular Edema/diagnosis/etiology
MH  - *Retinal Vein Occlusion
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
EDAT- 2020/04/11 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/04/11 06:00
PHST- 2019/12/14 00:00 [received]
PHST- 2020/01/22 00:00 [revised]
PHST- 2020/01/27 00:00 [accepted]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/04/11 06:00 [entrez]
AID - S0008-4182(19)31301-8 [pii]
AID - 10.1016/j.jcjo.2020.01.013 [doi]
PST - ppublish
SO  - Can J Ophthalmol. 2020 Aug;55(4):301-309. doi: 10.1016/j.jcjo.2020.01.013. Epub 
      2020 Apr 7.