PMID- 32273676
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 14
DP  - 2020
TI  - Factors Affecting Compliance to Anti-Vascular Endothelial Growth Factor Treatment 
      of Diabetic Macular Edema in a Cohort of Jordanian Patients.
PG  - 921-929
LID - 10.2147/OPTH.S248661 [doi]
AB  - PURPOSE: To determine compliance rates and characteristics and to investigate 
      factors affecting patients' adherence to treatment with anti-vascular endothelial 
      growth factors (anti-VEGFs) for diabetic macular edema (DME) in a cohort of 
      Jordanian patients. METHODS: A retrospective case series wherein the files of DME 
      patients treated with anti-VEGFs were reviewed and analyzed for factors affecting 
      treatment compliance was undertaken. Demographic, clinical and ocular 
      characteristics were recorded. All patients were also interviewed by phone using 
      a structured questionnaire. Univariate and multivariate analyses were performed 
      to determine factors associated with compliance. RESULTS: A total of 117 patients 
      (65 males 52 females) were included in this study with a mean age of 62.93 years 
      (+/-9.75). Approximately, 85% of patients were compliant to their treatment and 
      follow-up plan during the first year of management. Subjective perception of 
      visual improvement after receiving three loading doses was the only independent 
      variable with a unique statistically significant contribution to compliance. All 
      other studied factors in this group of patients were not significantly associated 
      with patient compliance. CONCLUSION: VEGF suppression via the intravitreal route 
      to treat DME is a long-term process that requires caregiver dedication but also 
      proper patient compliance. Addressing real-life barriers in those patients may 
      help guide future strategies to improve the treatment experience, lower the 
      financial burden and contribute to better outcomes. Patients' perceptions of 
      possible treatment outcomes at the short term may influence their long-term 
      commitment to therapy.
CI  - (c) 2020 Abu-Yaghi et al.
FAU - Abu-Yaghi, Nakhleh E
AU  - Abu-Yaghi NE
AD  - Department of Special Surgery, Ophthalmology Division, The University of Jordan, 
      Amman, Jordan.
FAU - Abed, Alaa M
AU  - Abed AM
AUID- ORCID: 0000-0002-7602-2690
AD  - Department of Special Surgery, Ophthalmology Division, The University of Jordan, 
      Amman, Jordan.
FAU - Khlaifat, Dana F
AU  - Khlaifat DF
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
FAU - Nawaiseh, Mohammed B
AU  - Nawaiseh MB
AUID- ORCID: 0000-0002-6252-5713
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
FAU - Emoush, Laith O
AU  - Emoush LO
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
FAU - AlHajjaj, Heba Z
AU  - AlHajjaj HZ
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
FAU - Abojaradeh, Ala M
AU  - Abojaradeh AM
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
FAU - Hattar, Mariana N
AU  - Hattar MN
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
FAU - Abusaleem, Sura K
AU  - Abusaleem SK
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
FAU - Sabbagh, Hashem M
AU  - Sabbagh HM
AD  - Department of Special Surgery, Ophthalmology Division, The University of Jordan, 
      Amman, Jordan.
FAU - Abu Gharbieh, Yazan A
AU  - Abu Gharbieh YA
AUID- ORCID: 0000-0002-9549-9910
AD  - Department of Special Surgery, Ophthalmology Division, The University of Jordan, 
      Amman, Jordan.
FAU - Quaqazeh, Sura A
AU  - Quaqazeh SA
AD  - School of Medicine, The University of Jordan, Amman, Jordan.
LA  - eng
PT  - Journal Article
DEP - 20200324
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC7102883
OTO - NOTNLM
OT  - anti-vascular endothelial growth factor
OT  - compliance
OT  - diabetic macular edema
OT  - retinopathy
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/04/11 06:00
MHDA- 2020/04/11 06:01
PMCR- 2020/03/24
CRDT- 2020/04/11 06:00
PHST- 2020/02/06 00:00 [received]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/04/11 06:00 [entrez]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2020/04/11 06:01 [medline]
PHST- 2020/03/24 00:00 [pmc-release]
AID - 248661 [pii]
AID - 10.2147/OPTH.S248661 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2020 Mar 24;14:921-929. doi: 10.2147/OPTH.S248661. eCollection 
      2020.