PMID- 32273709
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 16
DP  - 2020
TI  - The Effect of Type 2 Diabetes Mellitus on Neuropsychological Symptoms in Chinese 
      Early Alzheimer's Disease Population.
PG  - 829-836
LID - 10.2147/NDT.S240529 [doi]
AB  - OBJECTIVE: To explore the effect of Type 2 diabetes mellitus (T2DM) on the 
      development of neuropsychiatric symptoms (NPS) in early Alzheimer's disease (AD). 
      METHODS: From September 2017 to March 2019, a cross-sectional study was conducted 
      on the clinical data of 158 early AD patients over 65 years old in the Department 
      of Neurology of Daping Hospital. All early stage of AD patients were divided into 
      early stage of AD with NPS group and early stage of AD without NPS group 
      according to the presence or absence of NPS. Clinical data of age, sex, body mass 
      index (BMI), smoking and alcohol consumption, history of hypertension, 
      hyperlipidemia, white matter leisure (WML) and T2DM, MMSE, CDR and NPI-Q scores 
      were collected. Multivariate logistic regression analyses were performed to 
      examine the relationship between T2DM and NPS in early AD. RESULTS: Compared with 
      the early stage of AD group without NPS, the early stage of AD group with NPS was 
      older, the proportion of women was higher, the proportion of T2DM, hypertension, 
      hyperlipidemia and WML was higher, and the MMSE score was lower (P< 0.05). T2DM 
      was an independent risk factor for NPS in early stage of AD patients (OR 3.48, 
      95% CI 2.91-3.84). The incidence of T2DM in AD patients with depression, anxiety, 
      nighttime behavioral disturbances, and appetite disturbances was significantly 
      higher than in AD patients without these symptoms. T2DM was an independent risk 
      factor of depression (OR 2.04, 95% CI 1.71-2.38), anxiety (OR 1.69, 95% CI 
      1.38-1.97), nighttime behavioral disturbances (OR 1.95, 95% CI 1.75-2.13) and 
      appetite disturbances (OR 1.62, 95% CI 1.33-1.94) in early AD patients. 
      CONCLUSION: T2DM was an important independent risk factor for NPS in early AD, 
      which promotes the occurrence of depression, anxiety, nighttime behavioral 
      disturbances and appetite disturbances in early AD.
CI  - (c) 2020 Shi et al.
FAU - Shi, Qianqian
AU  - Shi Q
AD  - Department of Neurology, Daping Hospital, Army Medical University, Chongqing 
      400042, People's Republic of China.
FAU - Zhou, Faying
AU  - Zhou F
AD  - Department of Neurology, Daping Hospital, Army Medical University, Chongqing 
      400042, People's Republic of China.
FAU - Mei, Jing
AU  - Mei J
AD  - Department of Neurology, Daping Hospital, Army Medical University, Chongqing 
      400042, People's Republic of China.
FAU - Yang, Haimei
AU  - Yang H
AD  - Department of Neurology, Daping Hospital, Army Medical University, Chongqing 
      400042, People's Republic of China.
FAU - Li, Huiyun
AU  - Li H
AUID- ORCID: 0000-0002-7682-5776
AD  - Department of Neurology, Daping Hospital, Army Medical University, Chongqing 
      400042, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200326
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC7105356
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - neuropsychiatric symptoms
OT  - type 2 diabetes
COIS- The authors declare that they have no conflicts of interest in this work.
EDAT- 2020/04/11 06:00
MHDA- 2020/04/11 06:01
PMCR- 2020/03/26
CRDT- 2020/04/11 06:00
PHST- 2019/11/29 00:00 [received]
PHST- 2020/03/01 00:00 [accepted]
PHST- 2020/04/11 06:00 [entrez]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2020/04/11 06:01 [medline]
PHST- 2020/03/26 00:00 [pmc-release]
AID - 240529 [pii]
AID - 10.2147/NDT.S240529 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2020 Mar 26;16:829-836. doi: 10.2147/NDT.S240529. 
      eCollection 2020.