PMID- 32273741
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 13
DP  - 2020
TI  - SLC30A8, CDKAL1, TCF7L2, KCNQ1 and IGF2BP2 are Associated with Type 2 Diabetes 
      Mellitus in Iranian Patients.
PG  - 897-906
LID - 10.2147/DMSO.S225968 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a serious public health issue with 
      significantly increasing rates across the world. The genome-wide association 
      studies (GWAS) have previously manifested involved genes that remarkably enhance 
      the risk of T2DM. In this study, the association of common variants with T2DM 
      risk has been identified among Iranian population from Tehran province of Iran. 
      METHODS: Here, the association of refSNPs with T2DM risk was examined on 
      peripheral blood samples of 268 individuals including control group and patients 
      with T2DM using the tetra amplification refractory mutation system (ARMS) methods 
      and direct genomic DNA sequencing. RESULTS: Our study demonstrated that SLC30A8 
      rs13266634 (T/C), CDKAL1 rs10946398 (A/C), TCF7L2 rs7903146 (C/T), KCNQ1 
      rs2237892 (T/C), and IGF2BP2 rs1470579 (A/C) polymorphisms are significantly 
      associated with type 2 diabetes, but no significant association was identified 
      for FTO rs8050136 and MTNR1B rs10830963 polymorphisms. CONCLUSION: The prediction 
      of refSNPs is remarkably needed for pharmacogenetics and pharmacogenomic 
      approaches, in which the information would be useful for clinicians to optimize 
      therapeutic strategies and adverse drug reactions in patients with T2DM.
CI  - (c) 2020 Vatankhah Yazdi et al.
FAU - Vatankhah Yazdi, Kazem
AU  - Vatankhah Yazdi K
AD  - Department of Genetic, Shahid Sadoughi University of Medical Sciences and Health 
      Services, Yazd, Iran.
FAU - Kalantar, Seyed Mehdi
AU  - Kalantar SM
AD  - Department of Genetic, Shahid Sadoughi University of Medical Sciences and Health 
      Services, Yazd, Iran.
FAU - Houshmand, Massoud
AU  - Houshmand M
AD  - Department of Medical Genetics, National Institute for Genetic Engineering and 
      Biotechnology (NIGEB), Tehran, Iran.
AD  - Research Center, Knowledge University, Erbil, Kurdistan Region, Iraq.
FAU - Rahmanian, Masoud
AU  - Rahmanian M
AD  - Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences and 
      Health Services, Yazd, Iran.
FAU - Manaviat, Masoud Reza
AU  - Manaviat MR
AD  - Department of Ophthalmology, Shahid Sadoughi University of Medical Sciences and 
      Health Services, Yazd, Iran.
FAU - Jahani, Mohammad Reza
AU  - Jahani MR
AUID- ORCID: 0000-0003-2406-6162
AD  - Taban Health Care and Diabetes Clinic Lab, Tehran, Iran.
FAU - Kamalidehghan, Behnam
AU  - Kamalidehghan B
AD  - Department of Medical Genetics, National Institute for Genetic Engineering and 
      Biotechnology (NIGEB), Tehran, Iran.
AD  - Medical Genetics Department, Jiroft University of Medical Sciences and Health 
      Services, Jiroft, Iran.
FAU - Almasi-Hashiani, Amir
AU  - Almasi-Hashiani A
AUID- ORCID: 0000-0003-4434-561X
AD  - Department of Epidemiology, School of Health, Arak University of Medical 
      Sciences, Arak, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200324
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7102914
OTO - NOTNLM
OT  - ARMS
OT  - GWAS
OT  - Iranian populations
OT  - T2DM
OT  - the genome-wide association studies
OT  - the tetra amplification refractory mutation system
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/04/11 06:00
MHDA- 2020/04/11 06:01
PMCR- 2020/03/24
CRDT- 2020/04/11 06:00
PHST- 2019/08/04 00:00 [received]
PHST- 2020/02/18 00:00 [accepted]
PHST- 2020/04/11 06:00 [entrez]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2020/04/11 06:01 [medline]
PHST- 2020/03/24 00:00 [pmc-release]
AID - 225968 [pii]
AID - 10.2147/DMSO.S225968 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2020 Mar 24;13:897-906. doi: 10.2147/DMSO.S225968. 
      eCollection 2020.