PMID- 32274178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220817
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 12
IP  - 3
DP  - 2020 Mar
TI  - Idiopathic subglottic stenosis: a review.
PG  - 1100-1111
LID - 10.21037/jtd.2019.11.43 [doi]
AB  - Idiopathic subglottic stenosis (iSGS) is a fibrotic disease of unclear etiology 
      that produces obstruction of the central airway in the anatomic region under the 
      glottis. The diagnosis of this entity is difficult, usually delayed and 
      confounded with other common respiratory diseases. No apparent etiology is 
      identified even after a comprehensive workup that includes a complete history, 
      physical examination, pulmonary function testing, auto-antibodies, imaging 
      studies, and endoscopic procedures. This approach, however, helps to exclude 
      other conditions such as granulomatosis with polyangiitis (GPA). It is also 
      helpful to characterize the lesion and outline management strategies. Therapeutic 
      endoscopic procedures and surgery are the most common management modalities, but 
      medical therapy can also play a significant role in preventing or delaying 
      recurrence. In this review, we describe the morphology, pathophysiology, clinical 
      presentation, evaluation, management, and prognosis of iSGS.
CI  - 2020 Journal of Thoracic Disease. All rights reserved.
FAU - Aravena, Carlos
AU  - Aravena C
AD  - Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, 
      Cleveland, OH, USA.
AD  - Department of Respiratory Diseases, Faculty of Medicine, Pontificia Universidad 
      Catolica de Chile, Santiago, Chile.
FAU - Almeida, Francisco A
AU  - Almeida FA
AD  - Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, 
      Cleveland, OH, USA.
FAU - Mukhopadhyay, Sanjay
AU  - Mukhopadhyay S
AD  - Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine 
      Institute, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
FAU - Ghosh, Subha
AU  - Ghosh S
AD  - Department of Diagnostic Radiology, Heart and Vascular Institute, Cleveland 
      Clinic, Cleveland, OH, USA.
FAU - Lorenz, Robert R
AU  - Lorenz RR
AD  - Head and Neck Institute, Heart and Vascular Institute, Cleveland Clinic, 
      Cleveland, OH, USA.
FAU - Murthy, Sudish C
AU  - Murthy SC
AD  - Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, 
      Cleveland Clinic, Cleveland, OH, USA.
FAU - Mehta, Atul C
AU  - Mehta AC
AD  - Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, 
      Cleveland, OH, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC7139051
OTO - NOTNLM
OT  - Idiopathic subglottic stenosis (iSGS)
OT  - granulomatosis with polyangiitis (GPA)
OT  - laryngostenosis
OT  - subglottic stenosis (SGS)
OT  - tracheal stenosis
COIS- Conflicts of Interest: The series "Interventional Pulmonology" was commissioned 
      by the editorial office without any funding or sponsorship. The authors have no 
      other conflicts of interest to declare.
EDAT- 2020/04/11 06:00
MHDA- 2020/04/11 06:01
PMCR- 2020/03/01
CRDT- 2020/04/11 06:00
PHST- 2020/04/11 06:00 [entrez]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2020/04/11 06:01 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - jtd-12-03-1100 [pii]
AID - 10.21037/jtd.2019.11.43 [doi]
PST - ppublish
SO  - J Thorac Dis. 2020 Mar;12(3):1100-1111. doi: 10.21037/jtd.2019.11.43.