PMID- 32275364
OWN - NLM
STAT- MEDLINE
DCOM- 20200728
LR  - 20200728
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 40
IP  - 4
DP  - 2020 Apr 12
TI  - [Clinical efficacy of different waves of electroacupuncture on knee 
      osteoarthritis and its effect on TGF-beta1 in joint fluid].
PG  - 370-4
LID - 10.13703/j.0255-2930.20190422-0005 [doi]
AB  - OBJECTIVE: To observe the therapeutic effects of different waves of 
      electroacupuncture (EA) on knee osteoarthritis (KOA), and to explore the 
      mechanism of different waves of EA on promoting cartilage repair. METHODS: 
      Ninety- seven patients with KOA were randomly divided into a dilatational wave 
      group (32 cases, 2 cases dropped off), a continuous wave group (32 cases, 2 cases 
      dropped off) and a discontinuous wave group (33 cases, 3 cases dropped off). The 
      same acupoints of Xuehai (SP 10), Liangqiu (ST 34), Dubi (ST 35) and Neixiyan 
      (EX-LE 4) were selected in the three groups. The dilatational wave (frequency of 
      2 Hz/10 Hz) was used in the dilatational wave group, the continuous wave 
      (frequency of 10 Hz) was used in the continuous wave group, and the discontinuous 
      wave (frequency of 10 Hz) was used in the discontinuous wave group. All the 
      needles were retained for 30 min. All the treatment was given 3 times a week (on 
      Monday, Wednesday and Friday) for 4 weeks. Lysholm knees scoring scale (LKSS) was 
      used to evaluate the knee joint function before and after treatment, and the 
      content of transforming growth factor-beta1 (TGF-beta1) in the joint effusion before 
      and after treatment was determined by enzyme-linked immunosorbent assay (ELISA). 
      RESULTS: Compared before treatment, the total score and each score of LKSS were 
      increased after treatment in the three groups (all P<0.05). The improvements of 
      total score, pain score, instability score, swelling score of LKSS in the 
      continuous wave group and the dilatational wave group were superior to those in 
      the discontinuous wave group (all P<0.05). The content of TGF-beta1 in the joint 
      effusion in each group was increased after treatment (P<0.05), and the 
      improvement in dilatational wave group was superior to thoes in the continuous 
      wave group and the discontinuous wave group (all P<0.05). CONCLUSION: The three 
      different waves of EA could all improve the clinical symptoms of KOA, which may 
      promote cartilage repair by increasing TGF-beta1 content. The dilatational wave had 
      the best overall effect, which can be used as a clinical optimal treatment.
FAU - Huang, Dong-E
AU  - Huang DE
AD  - Department of Physical Therapy of TCM, the 900th Hospital of Joint Service Corps 
      of Chinese PLA, Fuzhou 350025, Fujian Province, China.
FAU - Qin, Yin
AU  - Qin Y
AD  - Department of Physical Therapy of TCM, the 900th Hospital of Joint Service Corps 
      of Chinese PLA, Fuzhou 350025, Fujian Province, China.
FAU - Lin, Mu-Nan
AU  - Lin MN
AD  - Department of Physical Therapy of TCM, the 900th Hospital of Joint Service Corps 
      of Chinese PLA, Fuzhou 350025, Fujian Province, China.
FAU - Lai, Xiao-Ling
AU  - Lai XL
AD  - Department of Physical Therapy of TCM, the 900th Hospital of Joint Service Corps 
      of Chinese PLA, Fuzhou 350025, Fujian Province, China.
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Acupuncture Points
MH  - *Electroacupuncture
MH  - Humans
MH  - Knee Joint
MH  - Osteoarthritis, Knee/*therapy
MH  - Synovial Fluid/*chemistry
MH  - Transforming Growth Factor beta1/*analysis
MH  - Treatment Outcome
OTO - NOTNLM
OT  - electroacupuncture (EA)
OT  - knee osteoarthritis (KOA)
OT  - randomized controlled trial (RCT)
OT  - transforming growth factor-beta1 (TGF-beta1)
OT  - waveform
EDAT- 2020/04/11 06:00
MHDA- 2020/07/29 06:00
CRDT- 2020/04/11 06:00
PHST- 2020/04/11 06:00 [entrez]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2020/07/29 06:00 [medline]
AID - 10.13703/j.0255-2930.20190422-0005 [doi]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2020 Apr 12;40(4):370-4. doi: 
      10.13703/j.0255-2930.20190422-0005.