PMID- 32275864
OWN - NLM
STAT- MEDLINE
DCOM- 20210512
LR  - 20231112
IS  - 2451-9448 (Electronic)
IS  - 2451-9456 (Print)
IS  - 2451-9448 (Linking)
VI  - 27
IP  - 4
DP  - 2020 Apr 16
TI  - Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating 
      Ferroptosis.
PG  - 436-447
LID - S2451-9456(20)30108-2 [pii]
LID - 10.1016/j.chembiol.2020.03.011 [doi]
AB  - Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and 
      lipid peroxidation dependent. As new mechanistic insight into ferroptotic 
      effectors and how they are regulated in different disease contexts is uncovered, 
      our understanding of the physiological and pathological relevance of this mode of 
      cell death continues to grow. Along these lines, a host of pharmacological 
      modulators of this pathway have been identified, targeting proteins involved in 
      iron homeostasis; the generation and reduction of lipid peroxides; or cystine 
      import and glutathione metabolism. Also, of note, many components of the 
      ferroptosis cascade are target genes of the transcription factor nuclear factor 
      erythroid 2-related factor 2 (NRF2), indicating its critical role in mediating 
      the ferroptotic response. In this review, we discuss the in vitro, in vivo, and 
      clinical evidence of ferroptosis in disease, including a brief discussion of 
      targeting upstream mediators of this cascade, including NRF2, to treat 
      ferroptosis-driven diseases.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Anandhan, Annadurai
AU  - Anandhan A
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA.
FAU - Dodson, Matthew
AU  - Dodson M
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA.
FAU - Schmidlin, Cody J
AU  - Schmidlin CJ
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA.
FAU - Liu, Pengfei
AU  - Liu P
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA.
FAU - Zhang, Donna D
AU  - Zhang DD
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA; University of Arizona 
      Cancer Center, University of Arizona, Tucson, AZ 85724, USA. Electronic address: 
      dzhang@pharmacy.arizona.edu.
LA  - eng
GR  - T32 ES007091/ES/NIEHS NIH HHS/United States
GR  - P30 ES006694/ES/NIEHS NIH HHS/United States
GR  - R35 ES031575/ES/NIEHS NIH HHS/United States
GR  - R01 ES026845/ES/NIEHS NIH HHS/United States
GR  - P42 ES004940/ES/NIEHS NIH HHS/United States
GR  - R01 DK109555/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20200409
PL  - United States
TA  - Cell Chem Biol
JT  - Cell chemical biology
JID - 101676030
RN  - 0 (Cation Transport Proteins)
RN  - 0 (Lipid Peroxides)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Receptors, Transferrin)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.11.1.12 (Phospholipid Hydroperoxide Glutathione Peroxidase)
SB  - IM
MH  - Cation Transport Proteins/metabolism
MH  - *Ferroptosis
MH  - Humans
MH  - Iron/metabolism
MH  - Lipid Peroxidation
MH  - Lipid Peroxides/metabolism
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Neoplasms/metabolism/pathology
MH  - Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism
MH  - Receptors, Transferrin/metabolism
PMC - PMC7597851
MID - NIHMS1640241
OTO - NOTNLM
OT  - NRF2
OT  - cancer
OT  - cardiovascular disease
OT  - cell death
OT  - diabetes
OT  - ferritinophagy
OT  - ferroptosis
OT  - iron
OT  - lipid peroxidation
OT  - neurodegeneration
EDAT- 2020/04/11 06:00
MHDA- 2021/05/13 06:00
PMCR- 2021/04/16
CRDT- 2020/04/11 06:00
PHST- 2019/11/04 00:00 [received]
PHST- 2020/02/05 00:00 [revised]
PHST- 2020/03/12 00:00 [accepted]
PHST- 2020/04/11 06:00 [pubmed]
PHST- 2021/05/13 06:00 [medline]
PHST- 2020/04/11 06:00 [entrez]
PHST- 2021/04/16 00:00 [pmc-release]
AID - S2451-9456(20)30108-2 [pii]
AID - 10.1016/j.chembiol.2020.03.011 [doi]
PST - ppublish
SO  - Cell Chem Biol. 2020 Apr 16;27(4):436-447. doi: 10.1016/j.chembiol.2020.03.011. 
      Epub 2020 Apr 9.