PMID- 32276365
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 10
IP  - 4
DP  - 2020 Apr 8
TI  - Changes in Serotonin Modulation of Glutamate Currents in Pyramidal Offspring 
      Cells of Rats Treated With 5-MT during Gestation.
LID - 10.3390/brainsci10040221 [doi]
LID - 221
AB  - Changes in stimuli and feeding in pregnant mothers alter the behavior of 
      offspring. Since behavior is mediated by brain activity, it is expected that 
      postnatal changes occur at the level of currents, receptors or soma and dendrites 
      structure and modulation. In this work, we explore at the mechanism level the 
      effects on Sprague-Dawley rat offspring following the administration of serotonin 
      (5-HT) agonist 5-methoxytryptamine (5-MT). We analyzed whether 5-HT affects the 
      glutamate-activated (I(Glut)) and N-methyl-D-aspartate (NMDA)-activated currents 
      (I(Glut), I(NMDA)) in dissociated pyramidal neurons from the prefrontal cortex 
      (PFC). For this purpose, we performed voltage-clamp experiments on pyramidal 
      neurons from layers V-VI of the PFC of 40-day-old offspring born from 
      5-MT-treated mothers at the gestational days (GD) 11 to 21. We found that the 
      pyramidal-neurons from the PFC of offspring of mothers treated with 5-MT exhibit 
      a significant increased reduction in both the I(Glut) and I(NMDA) when 5-HT was 
      administered. Our results suggest that the concentration increase of a 
      neuromodulator during the gestation induces changes in its modulatory action over 
      the offspring ionic currents during the adulthood thus contributing to possible 
      psychiatric disorders.
FAU - Hernandez-Carballo, Gustavo
AU  - Hernandez-Carballo G
AUID- ORCID: 0000-0002-7589-6679
AD  - Instituto de Fisiologia Benemerita Universidad Autonoma de Puebla, Puebla 
      C.P.72570, Mexico.
FAU - Ruiz-Luna, Evelyn A
AU  - Ruiz-Luna EA
AD  - Instituto de Fisiologia Benemerita Universidad Autonoma de Puebla, Puebla 
      C.P.72570, Mexico.
FAU - Lopez-Lopez, Gustavo
AU  - Lopez-Lopez G
AD  - Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de Puebla, Puebla 
      C.P.72570, Mexico.
FAU - Manjarrez, Elias
AU  - Manjarrez E
AD  - Instituto de Fisiologia Benemerita Universidad Autonoma de Puebla, Puebla 
      C.P.72570, Mexico.
FAU - Flores-Hernandez, Jorge
AU  - Flores-Hernandez J
AUID- ORCID: 0000-0002-7394-3208
AD  - Instituto de Fisiologia Benemerita Universidad Autonoma de Puebla, Puebla 
      C.P.72570, Mexico.
LA  - eng
GR  - 441033/Consejo Nacional de Ciencia y Tecnologia/
GR  - VIEP/1944/2016/Vicerrectoria de Investigacion y Estudios de Posgrado de la 
      Benemerita Universidad Autonoma de Puebla/
PT  - Journal Article
DEP - 20200408
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC7225987
OTO - NOTNLM
OT  - 5-HT
OT  - 5-MT
OT  - NMDA
OT  - development
OT  - glutamate
OT  - hyperserotonemia
OT  - ionic currents
OT  - neurodevelopment
OT  - neuromodulation
OT  - neurotransmitters
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/12 06:00
MHDA- 2020/04/12 06:01
PMCR- 2020/04/01
CRDT- 2020/04/12 06:00
PHST- 2020/02/27 00:00 [received]
PHST- 2020/04/01 00:00 [revised]
PHST- 2020/04/03 00:00 [accepted]
PHST- 2020/04/12 06:00 [entrez]
PHST- 2020/04/12 06:00 [pubmed]
PHST- 2020/04/12 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - brainsci10040221 [pii]
AID - brainsci-10-00221 [pii]
AID - 10.3390/brainsci10040221 [doi]
PST - epublish
SO  - Brain Sci. 2020 Apr 8;10(4):221. doi: 10.3390/brainsci10040221.