PMID- 32276412
OWN - NLM
STAT- MEDLINE
DCOM- 20201214
LR  - 20210211
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 4
DP  - 2020 Apr 8
TI  - Bone Metabolism and Vitamin D Implication in Gastroenteropancreatic 
      Neuroendocrine Tumors.
LID - 10.3390/nu12041021 [doi]
LID - 1021
AB  - Patients affected by gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) have 
      an increased risk of developing osteopenia and osteoporosis, as several factors 
      impact on bone metabolism in these patients. In fact, besides the direct effect 
      of bone metastasis, bone health can be affected by hormone hypersecretion 
      (including serotonin, cortisol, and parathyroid hormone-related protein), 
      specific microRNAs, nutritional status (which in turn could be affected by 
      medical and surgical treatments), and vitamin D deficiency. In patients with 
      multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome associated with 
      NET occurrence, bone damage may carry other consequences. Osteoporosis may 
      negatively impact on the quality of life of these patients and can increment the 
      cost of medical care since these patients usually live with their disease for a 
      long time. However, recommendations suggesting screening to assess bone health in 
      GEP-NET patients are missing. The aim of this review is to critically analyze 
      evidence on the mechanisms that could have a potential impact on bone health in 
      patients affected by GEP-NET, focusing on vitamin D and its role in GEP-NET, as 
      well as on factors associated with MEN1 that could have an impact on bone 
      homeostasis.
FAU - Altieri, Barbara
AU  - Altieri B
AUID- ORCID: 0000-0003-2616-3249
AD  - Division of Endocrinology and Diabetes, Department of Internal Medicine I, 
      University Hospital, University of Wuerzburg, 97080 Wuerzburg, Germany.
FAU - Di Dato, Carla
AU  - Di Dato C
AD  - Department of Clinical Medicine, Bufalini Hospital, 47521 Cesena, Italy.
FAU - Modica, Roberta
AU  - Modica R
AD  - Department of Clinical Medicine and Surgery, Federico II University, 80131 
      Naples, Italy.
FAU - Bottiglieri, Filomena
AU  - Bottiglieri F
AD  - Department of Clinical Medicine and Surgery, Federico II University, 80131 
      Naples, Italy.
FAU - Di Sarno, Antonella
AU  - Di Sarno A
AD  - UOC of Internal Medicine, AO dei Colli, Monaldi Unit, 80131 Naples, Italy.
FAU - Pittaway, James F H
AU  - Pittaway JFH
AD  - Centre for Endocrinology, William Harvey Research Institute, Barts and the London 
      School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ 
      London, UK.
FAU - Martini, Chiara
AU  - Martini C
AD  - Clinica Medica 3, Department of Medicine, DIMED, University of Padova, 35128 
      Padova, Italy.
FAU - Faggiano, Antongiulio
AU  - Faggiano A
AUID- ORCID: 0000-0002-9324-3946
AD  - Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, 
      Italy.
FAU - Colao, Annamaria
AU  - Colao A
AD  - Department of Clinical Medicine and Surgery, Federico II University, 80131 
      Naples, Italy.
LA  - eng
GR  - MR/S022155/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20200408
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (MicroRNAs)
RN  - 1406-16-2 (Vitamin D)
RN  - Gastro-enteropancreatic neuroendocrine tumor
SB  - IM
MH  - Bone Density
MH  - Bone Diseases, Metabolic/etiology
MH  - Bone Remodeling
MH  - Bone and Bones/*metabolism
MH  - Humans
MH  - Intestinal Neoplasms/complications/*physiopathology
MH  - MicroRNAs/metabolism
MH  - Multiple Endocrine Neoplasia Type 1/complications/physiopathology
MH  - Neuroendocrine Tumors/complications/*physiopathology
MH  - *Nutritional Status
MH  - Osteoporosis/etiology
MH  - Pancreatic Neoplasms/complications/*physiopathology
MH  - Quality of Life
MH  - Stomach Neoplasms/complications/*physiopathology
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/etiology
PMC - PMC7230756
OTO - NOTNLM
OT  - MEN1
OT  - bone
OT  - cortisol
OT  - miRNA
OT  - mineral bone density
OT  - neuroendocrine tumor
OT  - osteoporosis
OT  - serotonin
OT  - therapy
OT  - vitamin D
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/12 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/04/01
CRDT- 2020/04/12 06:00
PHST- 2020/03/03 00:00 [received]
PHST- 2020/03/30 00:00 [revised]
PHST- 2020/04/03 00:00 [accepted]
PHST- 2020/04/12 06:00 [entrez]
PHST- 2020/04/12 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - nu12041021 [pii]
AID - nutrients-12-01021 [pii]
AID - 10.3390/nu12041021 [doi]
PST - epublish
SO  - Nutrients. 2020 Apr 8;12(4):1021. doi: 10.3390/nu12041021.