PMID- 32276832 OWN - NLM STAT- MEDLINE DCOM- 20210708 LR - 20210708 IS - 2352-3840 (Electronic) IS - 1499-2671 (Linking) VI - 44 IP - 7 DP - 2020 Oct TI - Diabetic Peripheral Neuropathy Is Associated With Higher Systolic Blood Pressure in Adults With Type 2 Diabetes With and Without Hypertension in the Chinese Han Population. PG - 615-623 LID - S1499-2671(19)30729-4 [pii] LID - 10.1016/j.jcjd.2019.11.005 [doi] AB - OBJECTIVES: Our aim in this study was to investigate the association between diabetic peripheral neuropathy (DPN) and above-normal blood pressure in nonhypertensive adult patients with type 2 diabetes mellitus (T2DM). We also compared achievement of clinical targets for DPN and non-DPN with T2DM. METHODS: A retrospective survey was administered to 3,810 patients with T2DM. Cases were grouped according to the Toronto Clinical Scoring System as follows: non-DPN, mild DPN, moderate DPN and severe DPN. A total of 1,835 patients (hypertensive, 1,247; nonhypertensive, 588) also underwent nerve conduction velocity testing, and then was divided into quartile groups. RESULTS: Irrespective of hypertension, systolic blood pressure (SBP) and glycated hemoglobin levels in the DPN group were higher than those in the non-DPN group (p<0.001). In hypertensive patients, blood pressure goal achievement was lower in the DPN group compared with the non-DPN group (31.1% vs 40.5%, p<0.05). Compared with the nerve conduction velocity Q1 (P75%) groups decreased by 62.2%, 68.2% and 78.0%, respectively. In the nonhypertensive patients, detection of optimal SBP was lower in the DPN group than in the non-DPN group (p<0.05). After adjusting for age, sex and diabetes duration (model 2), a 3-point higher DPN score on the Toronto Clinical Scoring System was associated with an SBP level of 4.2 mmHg higher (95% confidence interval, 0.01 to 0.17; p<0.01) in nonhypertensive patients with diabetes. CONCLUSIONS: DPN is associated with difficulty in hypertension management in T2DM. It is also associated with elevated systolic blood hypertension, even in nonhypertensive patients with diabetes. Elevated SBP in nonhypertensive T2DM may be also worthy of further attention. CI - Copyright (c) 2019. Published by Elsevier Inc. FAU - Huang, Lingning AU - Huang L AD - Endocrinology Department, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Zhang, Yongze AU - Zhang Y AD - Endocrinology Department, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Wang, Yunmin AU - Wang Y AD - Endocrinology Department, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Shen, Ximei AU - Shen X AD - Endocrinology Department, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. FAU - Yan, Sunjie AU - Yan S AD - Endocrinology Department, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China; Diabetes Research Institute of Fujian Province, Fuzhou, Fujian, China. Electronic address: yansunjiephd@sina.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20191209 PL - Canada TA - Can J Diabetes JT - Canadian journal of diabetes JID - 101148810 RN - 0 (Biomarkers) SB - IM MH - Aged MH - Aged, 80 and over MH - Biomarkers/analysis MH - China/epidemiology MH - Diabetes Mellitus, Type 2/*complications MH - Diabetic Neuropathies/epidemiology/etiology/*pathology MH - Female MH - Follow-Up Studies MH - Humans MH - Hypertension/epidemiology/etiology/*pathology MH - Male MH - Middle Aged MH - Prognosis MH - Retrospective Studies MH - Risk Factors OTO - NOTNLM OT - Toronto Clinical Scoring System OT - blood pressure management OT - diabetic peripheral neuropathy OT - hypertension OT - nerve conduction velocities OT - neuropathie diabetique peripherique OT - prise en charge de la pression arterielle OT - vitesses de conduite nerveuse EDAT- 2020/04/12 06:00 MHDA- 2021/07/09 06:00 CRDT- 2020/04/12 06:00 PHST- 2019/02/15 00:00 [received] PHST- 2019/11/20 00:00 [revised] PHST- 2019/11/25 00:00 [accepted] PHST- 2020/04/12 06:00 [pubmed] PHST- 2021/07/09 06:00 [medline] PHST- 2020/04/12 06:00 [entrez] AID - S1499-2671(19)30729-4 [pii] AID - 10.1016/j.jcjd.2019.11.005 [doi] PST - ppublish SO - Can J Diabetes. 2020 Oct;44(7):615-623. doi: 10.1016/j.jcjd.2019.11.005. Epub 2019 Dec 9.