PMID- 32278861
OWN - NLM
STAT- MEDLINE
DCOM- 20210830
LR  - 20210830
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 109
DP  - 2020 Aug
TI  - Activation of Fc gamma receptor IIb up-regulates the production of 
      interferon-alpha and interferon-gamma in porcine alveolar macrophages during 
      PRRSV infection.
PG  - 103696
LID - S0145-305X(20)30098-7 [pii]
LID - 10.1016/j.dci.2020.103696 [doi]
AB  - Porcine Fc gamma receptor IIb (FcgammaRIIb) has been cloned and characterized for 
      many years. However, the role of FcgammaRIIb in innate antiviral response to porcine 
      reproductive and respiratory syndrome virus (PRRSV) infection has not yet been 
      well investigated. In current study, our results showed that specific activation 
      of FcgammaRIIb in porcine alveolar macrophages (PAMs) significantly enhanced the 
      production of interferon-alpha (IFN-alpha) and interferon-gamma (IFN-gamma), and 
      significantly repressed the production of transforming growth factor beta 1 
      (TGF-beta1). In addition, our results showed that specific activation of FcgammaRIIb in 
      PAMs cells in PRRSV infection not only significantly increased the production of 
      IFN-alpha and IFN-gamma, but also significantly decreased the production of TGF-beta1, and 
      significantly inhibited PRRSV replication level. In summary, our studies 
      indicated that FcgammaRIIb signaling up-regulated the production of IFN-alpha and IFN-gamma 
      in PAMs cells in vitro, in response to PRRSV infection.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Zhang, Liujun
AU  - Zhang L
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, 450002, China.
FAU - Xia, Yuhao
AU  - Xia Y
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, 450002, China.
FAU - Li, Wen
AU  - Li W
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, 450002, China.
FAU - Sun, Yangyang
AU  - Sun Y
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, 450002, China.
FAU - Kong, Linghao
AU  - Kong L
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, 450002, China.
FAU - Xu, Pengli
AU  - Xu P
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, 450002, China.
FAU - Xia, Pingan
AU  - Xia P
AD  - College of Animal Science and Veterinary Medicine, Henan Agricultural University, 
      Zhengzhou, 450002, China. Electronic address: xpa88@163.com.
FAU - Yue, Junming
AU  - Yue J
AD  - Department of Pathology and Laboratory Medicine, University of Tennessee Health 
      Science Center, Memphis, TN, 38163, USA; Center for Cancer Research, University 
      of Tennessee Health Science Center, Memphis, TN, 38163, USA. Electronic address: 
      jyue@uthsc.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200409
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Fc gamma receptor IIB)
RN  - 0 (Interferon-alpha)
RN  - 0 (Receptors, IgG)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Gene Expression Regulation/immunology
MH  - Host-Pathogen Interactions/immunology
MH  - Interferon-alpha/genetics/*immunology/metabolism
MH  - Interferon-gamma/genetics/*immunology/metabolism
MH  - Macrophages, Alveolar/*immunology/metabolism/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/physiology
MH  - Receptors, IgG/*immunology/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Swine
OTO - NOTNLM
OT  - FcgammaRIIb
OT  - IFN-alpha
OT  - IFN-gamma
OT  - PRRSV
OT  - TGF-beta1
COIS- Declaration of competing interest The authors declare that they have no competing 
      interests.
EDAT- 2020/04/13 06:00
MHDA- 2021/08/31 06:00
CRDT- 2020/04/13 06:00
PHST- 2020/02/22 00:00 [received]
PHST- 2020/04/02 00:00 [revised]
PHST- 2020/04/02 00:00 [accepted]
PHST- 2020/04/13 06:00 [pubmed]
PHST- 2021/08/31 06:00 [medline]
PHST- 2020/04/13 06:00 [entrez]
AID - S0145-305X(20)30098-7 [pii]
AID - 10.1016/j.dci.2020.103696 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2020 Aug;109:103696. doi: 10.1016/j.dci.2020.103696. Epub 2020 
      Apr 9.