PMID- 32279398
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1529-8019 (Electronic)
IS  - 1396-0296 (Linking)
VI  - 33
IP  - 3
DP  - 2020 May
TI  - 5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, 
      current concepts, comparative efficacy, and safety.
PG  - e13379
LID - 10.1111/dth.13379 [doi]
AB  - Androgenetic alopecia (AGA) is a multifactorial disease that carries a 
      significant psychological burden with it. Dihydrotestosterone, the main 
      pathogenic androgen in AGA, is produced by conversion of testosterone, which is 
      catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and 
      dutasteride are inhibitors of these enzymes. Finasteride, which is a single 
      receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking 
      dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher 
      potency than its predecessor, finasteride. This review corroborates the evidence 
      of superiority of dutasteride over finasteride, and its comparable safety profile 
      concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Dhurat, Rachita
AU  - Dhurat R
AD  - Department of Dermatology, LTMMC and LTMGH, Mumbai, India.
FAU - Sharma, Aseem
AU  - Sharma A
AD  - Department of Dermatology, L.T.M.M.C. and L.T.M.G.H., Sion Hospital, Mumbai, 
      India.
FAU - Rudnicka, Lidia
AU  - Rudnicka L
AUID- ORCID: 0000-0002-8308-1023
AD  - Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
FAU - Kroumpouzos, George
AU  - Kroumpouzos G
AD  - Department of Dermatology, Alpert Medical School of Brown University, Providence, 
      Rhode Island, USA.
AD  - Department of Dermatology, Medical School of Jundiai, Sao Paulo, Brazil.
AD  - GK Dermatology, PC, South Weymouth, Massachusetts, USA.
FAU - Kassir, Martin
AU  - Kassir M
AD  - Worldwide Laser Institute, Dallas, Texas, USA.
FAU - Galadari, Hassan
AU  - Galadari H
AD  - College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 
      United Arab Emirates.
FAU - Wollina, Uwe
AU  - Wollina U
AD  - Department of Dermatology and Allergology, Stadtisches Klinikum Dresden, Academic 
      Teaching Hospital of the Technical University of Dresden, Dresden, Germany.
FAU - Lotti, Torello
AU  - Lotti T
AUID- ORCID: 0000-0003-0840-1936
AD  - University of Studies Guglielmo Marconi, Rome, Italy.
FAU - Golubovic, Masa
AU  - Golubovic M
AD  - Clinic for Dermatovenerology, Clinical Center Nis, Nis, Serbia.
FAU - Binic, Iva
AU  - Binic I
AD  - Psychiatry Clinic, Clinical Center Nis, Nis, Serbia.
FAU - Grabbe, Stephan
AU  - Grabbe S
AD  - Department of Dermatology, University Medical Center of the Johannes Gutenberg 
      University, Mainz, Germany.
FAU - Goldust, Mohamad
AU  - Goldust M
AUID- ORCID: 0000-0002-9615-1246
AD  - University of Rome G. Marconi, Rome, Italy.
AD  - Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
AD  - Department of Dermatology, University Hospital Basel, Basel, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200424
PL  - United States
TA  - Dermatol Ther
JT  - Dermatologic therapy
JID - 9700070
RN  - 0 (5-alpha Reductase Inhibitors)
RN  - 0 (Androgen Antagonists)
RN  - 57GNO57U7G (Finasteride)
RN  - O0J6XJN02I (Dutasteride)
SB  - IM
MH  - *5-alpha Reductase Inhibitors/adverse effects
MH  - Alopecia/drug therapy
MH  - Androgen Antagonists
MH  - Dutasteride/adverse effects
MH  - *Finasteride/adverse effects
MH  - Humans
OTO - NOTNLM
OT  - 5-alpha reductase inhibitors
OT  - androgenetic alopecia
OT  - dutasteride
OT  - finasteride
EDAT- 2020/04/13 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/04/13 06:00
PHST- 2019/12/27 00:00 [received]
PHST- 2020/03/15 00:00 [revised]
PHST- 2020/04/01 00:00 [accepted]
PHST- 2020/04/13 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/04/13 06:00 [entrez]
AID - 10.1111/dth.13379 [doi]
PST - ppublish
SO  - Dermatol Ther. 2020 May;33(3):e13379. doi: 10.1111/dth.13379. Epub 2020 Apr 24.