PMID- 32279406
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20220531
IS  - 1439-0396 (Electronic)
IS  - 0931-2439 (Print)
IS  - 0931-2439 (Linking)
VI  - 105
IP  - 1
DP  - 2021 Jan
TI  - Urinary excretion of advanced glycation end products in dogs and cats.
PG  - 149-156
LID - 10.1111/jpn.13347 [doi]
AB  - The present study was conducted with privately owned dogs and cats to investigate 
      whether a relationship exists between the dietary AGEs and the urinary excretion 
      of AGEs, as indication of possible effective absorption of those compounds in the 
      intestinal tract of pet carnivores. For this purpose, data were collected from 
      both raw fed and dry processed food (DPF) fed to dogs and cats, through spot 
      urine sampling and questionnaires. Raw pet food (RF, low in AGE diets) was fed as 
      a primary food source to 29 dogs and DPF to 28 dogs. Cats were categorized into 3 
      groups, which were RF (n = 15), DPF (n = 14) and dry and wet processed pet food 
      (DWF, n = 25). Urinary-free carboxymethyllysine (CML), carboxyethyllysine (CEL) 
      and lysinoalanine (LAL) were analysed using ultrahigh-performance liquid 
      chromatography (UHPLC)-mass spectrometry, and were standardized for variable 
      urine concentration by expressing the AGE concentrations as a ratio to urine 
      creatinine (Ucr) concentration (microg/micromol Ucr). Urinary excretion of CML, CEL and 
      LAL in dogs fed with DPF was 2.03, 2.14 and 3 times higher compared to dogs fed 
      with RF (p < .005). Similar to the dogs, a significant difference in CML:Ucr, 
      CEL:Ucr and LAL:Ucr between the three diet groups was observed in cats 
      (p-overall < 0.005, ANOVA), in which the RF fed group excreted less AGEs than the 
      other groups. Linear regression coefficients and SE of CML:Ucr, CEL:Ucr and 
      LAL:Ucr showed that body weight and neuter status were significantly correlated 
      with CML and CEL excretion, but not to LAL excretion. Our results revealed a 
      significant correlation between dietary AGEs and urinary excretion of free CML, 
      CEL and LAL, and also showed that endogenous formation of these AGEs occurs in 
      both dogs and cats under physiological conditions.
CI  - (c) 2020 The Authors. Journal of Animal Physiology and Animal Nutrition published 
      by Blackwell Verlag GmbH.
FAU - Palaseweenun, Pornsucha
AU  - Palaseweenun P
AUID- ORCID: 0000-0002-9315-9007
AD  - Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht 
      University, Utrecht, The Netherlands.
AD  - Department of Physiology, Faculty of Veterinary Medicine, Kasetsart University, 
      Bangkok, Thailand.
FAU - Hagen-Plantinga, Esther A
AU  - Hagen-Plantinga EA
AD  - Nutrissues Pet Nutrition Consultancy, Deventer, The Netherlands.
FAU - Schonewille, J Thomas
AU  - Schonewille JT
AD  - Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht 
      University, Utrecht, The Netherlands.
FAU - Koop, Gerrit
AU  - Koop G
AD  - Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht 
      University, Utrecht, The Netherlands.
FAU - Butre, Claire
AU  - Butre C
AD  - Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands.
FAU - Jonathan, Melliana
AU  - Jonathan M
AD  - Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands.
FAU - Wierenga, Peter A
AU  - Wierenga PA
AD  - Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands.
FAU - Hendriks, Wouter H
AU  - Hendriks WH
AD  - Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht 
      University, Utrecht, The Netherlands.
AD  - Animal Sciences, Wageningen University, Wageningen, The Netherlands.
LA  - eng
GR  - Scholarship from the Faculty of Veterinary Medicine, Kasetsart University, 
      Thailand/
PT  - Journal Article
DEP - 20200411
PL  - Germany
TA  - J Anim Physiol Anim Nutr (Berl)
JT  - Journal of animal physiology and animal nutrition
JID - 101126979
RN  - 0 (Glycation End Products, Advanced)
SB  - IM
MH  - Animals
MH  - Cats
MH  - Chromatography, Liquid/veterinary
MH  - *Diet/veterinary
MH  - Dogs
MH  - Glycation End Products, Advanced/*urine
PMC - PMC7818435
OTO - NOTNLM
OT  - advanced glycation end products
OT  - cats
OT  - diet
OT  - dogs
OT  - urinary excretion
COIS- The authors declared that the research was conducted in the absences of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2020/04/13 06:00
MHDA- 2021/10/16 06:00
PMCR- 2021/01/21
CRDT- 2020/04/13 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2020/02/18 00:00 [revised]
PHST- 2020/02/20 00:00 [accepted]
PHST- 2020/04/13 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2020/04/13 06:00 [entrez]
PHST- 2021/01/21 00:00 [pmc-release]
AID - JPN13347 [pii]
AID - 10.1111/jpn.13347 [doi]
PST - ppublish
SO  - J Anim Physiol Anim Nutr (Berl). 2021 Jan;105(1):149-156. doi: 10.1111/jpn.13347. 
      Epub 2020 Apr 11.