PMID- 32279929
OWN - NLM
STAT- MEDLINE
DCOM- 20200720
LR  - 20200720
IS  - 1532-1770 (Electronic)
IS  - 1521-6942 (Linking)
VI  - 33
IP  - 6
DP  - 2019 Dec
TI  - HLA risk alleles and gut microbiome in ankylosing spondylitis and rheumatoid 
      arthritis.
PG  - 101499
LID - S1521-6942(20)30016-4 [pii]
LID - 10.1016/j.berh.2020.101499 [doi]
AB  - Human leukocyte antigen (HLA) alleles are associated with a variety of autoimmune 
      diseases. The composition of gut microbiome can be influenced by host immunity, 
      which is partially regulated by HLA. In this review, first we provide evidence 
      from animal and human studies on: if and how HLA-B27, HLA-DRB1 (shared epitope 
      (SE)), and other HLA alleles alter the gut microbiome, then we analyzed the data 
      for several hypotheses to explain the mechanism(s) of HLA alleles influences on 
      gut microbiome, and finally, we discussed several potential clinical implications 
      of HLA alleles and microbial data, such as bacterial biomarkers for diagnosis, 
      treatment, and the screening of high-risk population.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Xu, Huji
AU  - Xu H
AD  - Department of Rheumatology and Immunology, Changzheng Hospital, Second Military 
      Medical University, Shanghai 200003, China; Beijing Tsinghua Chang Gung Hospital, 
      School of Clinical Medicine, Tsinghua University, Beijing, China; Peking-Tsinghua 
      Center for Life Sciences, Tsinghua University, Beijing 100084, China. Electronic 
      address: xuhuji@smmu.edu.cn.
FAU - Yin, Jian
AU  - Yin J
AD  - Department of Rheumatology and Immunology, Changzheng Hospital, Second Military 
      Medical University, Shanghai 200003, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200409
PL  - Netherlands
TA  - Best Pract Res Clin Rheumatol
JT  - Best practice & research. Clinical rheumatology
JID - 101121149
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - *Arthritis, Rheumatoid/immunology/microbiology
MH  - *Gastrointestinal Microbiome
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - *Spondylitis, Ankylosing/immunology/microbiology
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - HLA association
OT  - Microbiome
OT  - Rheumatoid arthritis
EDAT- 2020/04/14 06:00
MHDA- 2020/07/21 06:00
CRDT- 2020/04/14 06:00
PHST- 2020/04/14 06:00 [pubmed]
PHST- 2020/07/21 06:00 [medline]
PHST- 2020/04/14 06:00 [entrez]
AID - S1521-6942(20)30016-4 [pii]
AID - 10.1016/j.berh.2020.101499 [doi]
PST - ppublish
SO  - Best Pract Res Clin Rheumatol. 2019 Dec;33(6):101499. doi: 
      10.1016/j.berh.2020.101499. Epub 2020 Apr 9.