PMID- 32280716
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - Middle-Aged Indians with Type 2 Diabetes Are at Higher Risk of Biological Ageing 
      with Special Reference to Serum CDKN2A.
PG  - 7569259
LID - 10.1155/2020/7569259 [doi]
LID - 7569259
AB  - Sedentary lifestyle and high visceral adiposity have elevated the risk of type 2 
      diabetes (T2DM) among Indians at younger age. In this study, we aimed to 
      investigate the association of oxidative stress and chronic inflammatory 
      mediators with ageing with special reference to the biological ageing marker 
      cyclin-dependent kinase inhibitor 2A (CDKN2A) among middle-aged (31-50 years) 
      Indian healthy and T2DM subjects. Malondialdehyde (MDA), oxidized LDL (oxLDL), 
      interleukin-6 (IL-6), interleukin 1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), 
      monocyte chemoattractant protein-1 (MCP-1), and CDKN2A were measured in T2DM 
      patients (n = 80) and controls (n = 80) aged 31-50 years, further grouped into 
      G1: 31-40 years and G2: 41-50 years. IL-6, TNF-alpha, MCP-1, and CDKN2A showed a 
      significant association with ageing among both T2DM patients and controls. But 
      the strength of the association of MCP-1 and CKDN2A with ageing was significantly 
      stronger in T2DM patients than the controls. All the oxidative stress and 
      proinflammatory mediators showed nonsignificant associations with CDKN2A in the 
      controls. However, IL-6, TNF-alpha, and MCP-1 showed a strong association with CDKN2A 
      in T2DM patients. An increased risk of high levels of CDKN2A was found in G1 T2DM 
      patients (OR: 3.484 (95% CI: 1.246-9.747) p = 0.017) and G2 T2DM patients (OR: 
      5.000 (95% CI: 1.914-13.061), p = 0.001) with reference to the respective control 
      groups. Our study reveals that the middle-aged Indians with T2DM are at higher 
      risk of biological ageing. The development of T2DM is more common among 
      middle-aged Indians. T2DM may exacerbate the ageing process and may subsequently 
      predispose Indians to various age-related complications at a much early age.
CI  - Copyright (c) 2020 Joyita Banerjee et al.
FAU - Banerjee, Joyita
AU  - Banerjee J
AUID- ORCID: 0000-0002-8756-0574
AD  - Symbiosis School of Biological Sciences (Formerly Symbiosis School of Biomedical 
      Sciences), Symbiosis International (Deemed University), Lavale, Pune, India.
FAU - Dhas, Yogita
AU  - Dhas Y
AUID- ORCID: 0000-0003-2566-8341
AD  - Symbiosis School of Biological Sciences (Formerly Symbiosis School of Biomedical 
      Sciences), Symbiosis International (Deemed University), Lavale, Pune, India.
FAU - Mishra, Neetu
AU  - Mishra N
AUID- ORCID: 0000-0002-0526-2056
AD  - Symbiosis School of Biological Sciences (Formerly Symbiosis School of Biomedical 
      Sciences), Symbiosis International (Deemed University), Lavale, Pune, India.
LA  - eng
PT  - Journal Article
DEP - 20200323
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aging/*blood
MH  - Biomarkers/blood
MH  - Cyclin-Dependent Kinase Inhibitor p16/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - India
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC7128035
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this paper.
EDAT- 2020/04/14 06:00
MHDA- 2021/01/26 06:00
PMCR- 2020/03/23
CRDT- 2020/04/14 06:00
PHST- 2019/09/23 00:00 [received]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/04/14 06:00 [entrez]
PHST- 2020/04/14 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/03/23 00:00 [pmc-release]
AID - 10.1155/2020/7569259 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 Mar 23;2020:7569259. doi: 10.1155/2020/7569259. eCollection 
      2020.