PMID- 32281329
OWN - NLM
STAT- MEDLINE
DCOM- 20200414
LR  - 20221207
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 45
IP  - 6
DP  - 2020 Mar
TI  - [Study on treatment of "cytokine storm" by anti-2019-nCoV prescriptions based on 
      arachidonic acid metabolic pathway].
PG  - 1225-1231
LID - 10.19540/j.cnki.cjcmm.20200224.405 [doi]
AB  - Since the outbreak of 2019-nCoV, the epidemic has developed rapidly and the 
      situation is grim. LANCET figured out that the 2019-nCoV is closely related to 
      "cytokine storm". "Cytokine storm" is an excessive immune 
      response of the body to external stimuli such as viruses and bacteria. As the 
      virus attacking the body, it stimulates the secretion of a large number of 
      inflammatory factors: interleukin(IL), interferon(IFN), C-X-C motif 
      chemokine(CXCL) and so on, which lead to cytokine cascade reaction. With the 
      exudation of inflammatory factors, cytokines increase abnormally in tissues and 
      organs, interfering with the immune system, causing excessive immune response of 
      the body, resulting in diffuse damage of lung cells, pulmonary fibrosis, and 
      multiple organ damage, even death. Arachidonic acid(AA) metabolic pathway is 
      principally used to synthesize inflammatory cytokines, such as monocyte 
      chemotactic protein 1(MCP-1), tumor necrosis factor(TNF), IL, IFN, etc., which is 
      closely related to the occurrence, development and regression of inflammation. 
      Therefore, the inhibition of AA metabolism pathway is benefit for inhibiting the 
      release of inflammatory factors in the body and alleviating the "cytokine 
      storm". Based on the pharmacophore models of the targets on AA metabolic 
      pathway, the traditional Chinese medicine database 2009(TCMD 2009) was screened. 
      The potential herbs were ranked by the number of hit molecules, which were scored 
      by pharmacophore fit value. In the end, we obtained the potential active 
      prescriptions on "cytokine storm" according to the potential herbs in 
      the "National novel coronavirus pneumonia diagnosis and treatment plan(trial 
      version sixth)". The results showed that the hit components with the 
      inhibitory effect on AA were magnolignan Ⅰ, lonicerin and 
      physcion-8-O-beta-D-glucopy-ranoside, which mostly extracted from Magnoliae 
      Officinalis Cortex, Zingiberis Rhizoma Recens, Lonicerae Japonicae Flos, Rhei 
      Radix et Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma, Scutellariae Radix, 
      Gardeniae Fructus, Ginseng Radix et Rhizoma, Arctii Fructus, Dryopteridis 
      Crassirhizomatis Rhizoma, Paeoniaeradix Rubra, Dioscoreae Rhizoma. Finally the 
      anti-2019-nCoV prescriptions were analyzed to obtain the potential active 
      prescriptions on AA metabolic pathway, Huoxiang Zhengqi Capsules, Jinhua Qinggan 
      Granules, Lianhua Qingwen Capsules, Qingfei Paidu Decoction, Xuebijing Injection, 
      Reduning Injection and Tanreqing Injection were found that may prevent 2019-nCoV 
      via regulate cytokines. This study intends to provide reference for clinical use 
      of traditional Chinese medicine to resist new coronavirus.
FAU - Ren, Yue
AU  - Ren Y
AD  - State Administration of Traditional Chinese Medicine, Research Center of 
      Traditional Chinese Medicine-Information Engineering,Key Technology of 
      Traditional Chinese Medicine Pharmacy and New Drug Development Engineering 
      Research Center of Ministry of Education, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine Beijing 102488, China.
FAU - Yao, Mei-Cun
AU  - Yao MC
AD  - School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen 510275, China.
FAU - Huo, Xiao-Qian
AU  - Huo XQ
AD  - State Administration of Traditional Chinese Medicine, Research Center of 
      Traditional Chinese Medicine-Information Engineering,Key Technology of 
      Traditional Chinese Medicine Pharmacy and New Drug Development Engineering 
      Research Center of Ministry of Education, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine Beijing 102488, China.
FAU - Gu, Yu
AU  - Gu Y
AD  - State Administration of Traditional Chinese Medicine, Research Center of 
      Traditional Chinese Medicine-Information Engineering,Key Technology of 
      Traditional Chinese Medicine Pharmacy and New Drug Development Engineering 
      Research Center of Ministry of Education, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine Beijing 102488, China.
FAU - Zhu, Wei-Xing
AU  - Zhu WX
AD  - Qingyuan Hospital of Traditional Chinese Medicine Qingyuan 511500, China.
FAU - Qiao, Yan-Jiang
AU  - Qiao YJ
AD  - State Administration of Traditional Chinese Medicine, Research Center of 
      Traditional Chinese Medicine-Information Engineering,Key Technology of 
      Traditional Chinese Medicine Pharmacy and New Drug Development Engineering 
      Research Center of Ministry of Education, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine Beijing 102488, China.
FAU - Zhang, Yan-Ling
AU  - Zhang YL
AD  - State Administration of Traditional Chinese Medicine, Research Center of 
      Traditional Chinese Medicine-Information Engineering,Key Technology of 
      Traditional Chinese Medicine Pharmacy and New Drug Development Engineering 
      Research Center of Ministry of Education, School of Chinese Materia Medica, 
      Beijing University of Chinese Medicine Beijing 102488, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 27YG812J1I (Arachidonic Acid)
SB  - IM
MH  - Arachidonic Acid/*metabolism
MH  - Betacoronavirus
MH  - COVID-19
MH  - Coronavirus Infections/*drug therapy/*immunology
MH  - Cytokines/*immunology
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Humans
MH  - Medicine, Chinese Traditional
MH  - Metabolic Networks and Pathways
MH  - Pandemics
MH  - Pneumonia, Viral/*drug therapy/*immunology
MH  - SARS-CoV-2
MH  - COVID-19 Drug Treatment
OTO - NOTNLM
OT  - "cytokine storm"
OT  - 2019-nCoV
OT  - arachidonic acid metabolic pathway
OT  - traditional Chinese medicine
OT  - virtual screening
EDAT- 2020/04/14 06:00
MHDA- 2020/04/15 06:00
CRDT- 2020/04/14 06:00
PHST- 2020/04/14 06:00 [entrez]
PHST- 2020/04/14 06:00 [pubmed]
PHST- 2020/04/15 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20200224.405 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(6):1225-1231. doi: 
      10.19540/j.cnki.cjcmm.20200224.405.