PMID- 32281957
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1308-4488 (Electronic)
IS  - 1016-5169 (Linking)
VI  - 48
IP  - 3
DP  - 2020 Apr
TI  - Diagnostic values of edema-sensitive T2-weighted imaging, TSE T1-weighted early 
      contrast-enhanced imaging, late gadolinium enhancement, and the Lake Louise 
      criteria in assessing acute myocarditis: A single-center cardiac magnetic 
      resonance study.
PG  - 246-254
LID - 10.5543/tkda.2019.67467 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate the diagnostic accuracy of the 
      Lake Louise consensus criteria using cardiac magnetic resonance (CMR) imaging 
      assessment of edema, hyperemia, and late gadolinium enhancement (LGE) in the 
      diagnostic determination of acute myocarditis. METHODS: A total of 44 patients 
      with acute myocarditis and 24 healthy controls were included in this 
      retrospective study. The presence of edema was defined as a myocardial mean 
      signal intensity >1.9 times that of the skeletal muscle in the same slice on 
      T2-weighted short tau inversion-recovery sequences. Hyperemia was defined as an 
      early gadolinium enhancement ratio (EGEr) >/=4 calculated using the 
      contrast-enhancement of the myocardium and skeletal muscle on TSE T1-weighted 
      sequences, and LGE was assessed by visual examination. The reference methods used 
      to determine the presence of myocarditis were based on the European Society of 
      Cardiology Working Group on Myocardial and Pericardial Diseases guidelines for 
      clinical and biochemical findings. RESULTS: The diagnostic accuracy of edema, 
      hyperemia, LGE, and the Lake Louise criteria (at least 2 of 3 components) was 
      75.7%, 64.2%, 88.5%, and 84.2%, respectively. Among the 3 components of the Lake 
      Louise criteria, edema had the highest specificity (100%), and LGE had the 
      highest sensitivity (86%). The use of LGE and/or edema as a criterion for acute 
      myocarditis revealed the highest diagnostic accuracy (92.8%) among the CMR 
      sequences and combinations of components examined. CONCLUSION: LGE and/or edema 
      as a sole criterion for the diagnosis of acute myocarditis demonstrated better 
      diagnostic accuracy than the Lake Louise criteria. The use of EGEr did not 
      improve the performance of CMR-based diagnosis. Alternatives to the use of EGEr 
      are recommended for the diagnosis of acute myocarditis.
FAU - Alis, Deniz
AU  - Alis D
AD  - Department of Radiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular 
      Surgery Training and Research Hospital, Istanbul, Turkey.
FAU - Guler, Arda
AU  - Guler A
AD  - Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular 
      Surgery Training and Research Hospital, Istanbul, Turkey.
FAU - Asmakutlu, Ozan
AU  - Asmakutlu O
AD  - Department of Radiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular 
      Surgery Training and Research Hospital, Istanbul, Turkey.
FAU - Uygur, Begum
AU  - Uygur B
AD  - Department of Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular 
      Surgery Training and Research Hospital, Istanbul, Turkey.
FAU - Ordekci, Seyhan
AU  - Ordekci S
AD  - Department of Infectious Diseases, Istanbul Mehmet Akif Ersoy Thoracic and 
      Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
TT  - Akut miyokardit tanisinda kardiyak MRG incelemede T2-agirlikli odem duyarli 
      incelemenin, TSE T1-agirlikli erken kontrastli incelemenin, gec kontrast 
      tutulumunun ve Lake Louise konsensus kriterlerinin tanisal degeri.
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
RN  - 0 (Contrast Media)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Contrast Media/*administration & dosage
MH  - Edema/*diagnostic imaging/pathology
MH  - Female
MH  - Heart/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Hyperemia/*diagnostic imaging/pathology
MH  - Image Enhancement/instrumentation
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnosis/pathology
MH  - Myocardium/pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2020/04/14 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/04/14 06:00
PHST- 2020/04/14 06:00 [entrez]
PHST- 2020/04/14 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
AID - 10.5543/tkda.2019.67467 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2020 Apr;48(3):246-254. doi: 10.5543/tkda.2019.67467.