PMID- 32282121
OWN - NLM
STAT- MEDLINE
DCOM- 20211007
LR  - 20211007
IS  - 2410-8650 (Electronic)
IS  - 1607-551X (Linking)
VI  - 36
IP  - 8
DP  - 2020 Aug
TI  - Analysis the effect of miR-141-3p/HMGB1 in LPS-induced mucus production and the 
      apoptosis in nasal epithelial cells.
PG  - 622-629
LID - 10.1002/kjm2.12215 [doi]
AB  - Allergic rhinitis (AR) is an allergic disease characterized by immunoglobulin E 
      (IgE)-mediated type I hypersensitivity disorder. In the current study, we 
      illuminated the potential roles of microRNA-141-3p (miR-141-3p) in 
      lipopolysaccharide (LPS)-induced mucus production and the apoptosis in nasal 
      epithelial cells (NECs). We demonstrated that miR-141-3p was significantly 
      downregulated in nasal tissues from patients with AR and LPS-treated NECs. 
      Upregulation of miR-141-3p decreased the level of mucin 5AC (MUC5AC) in 
      LPS-treated NECs and induced NECs apoptosis. High Mobility Group Box 1 (HMGB1) 
      was proved as a target of miR-141-3p and miR-141-3p negatively regulated its 
      expression. In addition, we observed that HMGB1 was overexpressed in nasal 
      mucosal tissues from patients with AR and LPS-treated NECs. Finally, we proved 
      that miR-141-3p decreased the level of MUAC5AC in LPS-treated NECs through 
      regulating HMGB1. In conclusion, miR-141-3p inhibited LPS-induced MUAC5AC 
      production and the apoptosis of LPS-treated NECs by targeting HMGB1.
CI  - (c) 2020 The Authors. The Kaohsiung Journal of Medical Sciences published by John 
      Wiley & Sons Australia on behalf of Kaohsiung Medical University.
FAU - Zhu, Yong-Ming
AU  - Zhu YM
AD  - Department of Otolaryngology, Nantong Hospital of Traditional Chinese Medicine, 
      Nantong, Jiangsu, China.
FAU - Wu, Feng
AU  - Wu F
AUID- ORCID: 0000-0002-8035-3521
AD  - Department of Otolaryngology, The Second People's Hospital of Nantong, Nantong, 
      Jiangsu, China.
FAU - Zhou, Jie-Yu
AU  - Zhou JY
AD  - Department of Otolaryngology, Shanghai Ninth People's Hospital, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20200413
PL  - China (Republic : 1949- )
TA  - Kaohsiung J Med Sci
JT  - The Kaohsiung journal of medical sciences
JID - 100960562
RN  - 0 (HMGB1 Protein)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (MIRN141 microRNA, human)
RN  - 0 (MUC5AC protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Mucin 5AC)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Base Sequence
MH  - Down-Regulation/genetics
MH  - Epithelial Cells/*metabolism
MH  - Gene Silencing
MH  - HMGB1 Protein/*metabolism
MH  - Humans
MH  - Lipopolysaccharides
MH  - Mice, Inbred BALB C
MH  - MicroRNAs/genetics/*metabolism
MH  - Mucin 5AC/metabolism
MH  - Mucus/*metabolism
MH  - Nasal Mucosa/*pathology
MH  - Rhinitis, Allergic/genetics
OTO - NOTNLM
OT  - HMGB1
OT  - allergic rhinitis
OT  - miR-141-3p
OT  - nasal epithelial cell
EDAT- 2020/04/14 06:00
MHDA- 2021/10/08 06:00
CRDT- 2020/04/14 06:00
PHST- 2019/12/21 00:00 [received]
PHST- 2020/03/19 00:00 [accepted]
PHST- 2020/04/14 06:00 [pubmed]
PHST- 2021/10/08 06:00 [medline]
PHST- 2020/04/14 06:00 [entrez]
AID - 10.1002/kjm2.12215 [doi]
PST - ppublish
SO  - Kaohsiung J Med Sci. 2020 Aug;36(8):622-629. doi: 10.1002/kjm2.12215. Epub 2020 
      Apr 13.