PMID- 32282296
OWN - NLM
STAT- MEDLINE
DCOM- 20210319
LR  - 20210319
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 26
IP  - 36
DP  - 2020
TI  - Pro-inflammatory Cytokines in Acute Coronary Syndromes.
PG  - 4624-4647
LID - 10.2174/1381612826666200413082353 [doi]
AB  - BACKGROUND: Over the last decades, the role of inflammation and immune system 
      activation in the initiation and progression of coronary artery disease (CAD) has 
      been established. OBJECTIVES: The study aimed to present the interplay between 
      cytokines and their actions preceding and shortly after ACS. METHODS: We searched 
      in a systemic manner the most relevant articles to the topic of inflammation, 
      cytokines, vulnerable plaque and myocardial infarction in MEDLINE, COCHRANE and 
      EMBASE databases. RESULTS: Different classes of cytokines (intereleukin [IL]-1 
      family, Tumor necrosis factor-alpha (TNF-alpha) family, chemokines, adipokines, 
      interferons) are implicated in the entire process leading to destabilization of 
      the atherosclerotic plaque, and consequently, to the incidence of myocardial 
      infarction. Especially IL-1 and TNF-alpha family are involved in inflammatory cell 
      accumulation, vulnerable plaque formation, platelet aggregation, cardiomyocyte 
      apoptosis and adverse remodeling following the myocardial infarction. Several 
      cytokines such as IL-6, adiponectin, interferon-gamma, appear with significant 
      prognostic value in ACS patients. Thus, research interest focuses on the 
      modulation of inflammation in ACS to improve clinical outcomes. CONCLUSION: 
      Understanding the unique characteristics that accompany each cytokine-cytokine 
      receptor interaction could illuminate the signaling pathways involved in plaque 
      destabilization and indicate future treatment strategies to improve 
      cardiovascular prognosis in ACS patients.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Mourouzis, Konstantinos
AU  - Mourouzis K
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Oikonomou, Evangelos
AU  - Oikonomou E
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Siasos, Gerasimos
AU  - Siasos G
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Tsalamadris, Sotiris
AU  - Tsalamadris S
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Vogiatzi, Georgia
AU  - Vogiatzi G
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Antonopoulos, Alexios
AU  - Antonopoulos A
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Fountoulakis, Petros
AU  - Fountoulakis P
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Goliopoulou, Athina
AU  - Goliopoulou A
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Papaioannou, Spyridon
AU  - Papaioannou S
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
FAU - Tousoulis, Dimitris
AU  - Tousoulis D
AD  - 1st Department of Cardiology, 'Hippokration' Hospital, National and Kapodistrian 
      University of Athens Medical School, Athens, Greece.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Cytokines)
SB  - IM
MH  - *Acute Coronary Syndrome/drug therapy
MH  - *Coronary Artery Disease/drug therapy
MH  - Cytokines
MH  - Humans
MH  - Inflammation
MH  - *Myocardial Infarction
MH  - *Plaque, Atherosclerotic
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - adipokines
OT  - atherosclerosis
OT  - cytokines
OT  - inflammation
OT  - vulnerable plaque
EDAT- 2020/04/14 06:00
MHDA- 2021/03/20 06:00
CRDT- 2020/04/14 06:00
PHST- 2019/12/05 00:00 [received]
PHST- 2020/04/01 00:00 [accepted]
PHST- 2020/04/14 06:00 [pubmed]
PHST- 2021/03/20 06:00 [medline]
PHST- 2020/04/14 06:00 [entrez]
AID - CPD-EPUB-105763 [pii]
AID - 10.2174/1381612826666200413082353 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2020;26(36):4624-4647. doi: 10.2174/1381612826666200413082353.