PMID- 322829
OWN - NLM
STAT- MEDLINE
DCOM- 19770611
LR  - 20041117
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 4
IP  - 2
DP  - 1977 May
TI  - Slow infections of the central nervous system.
PG  - 81-8
AB  - This review describes the recent advances in slow infections of the nervous 
      system emphasizing the pathogenetic aspects of these diseases. A theoretical 
      model for the pathogenesis of subacute sclerosing panencephalitis (SSPE) is 
      proposed, illustrating the factors that may affect host response to the measles 
      virus and allow it to persist and produce the panencephalitis. The isolation of 
      an oncogenic virus from progressive multifocal leukoencephalopathy (PML) has 
      implications in the consideration of a viral etiology for some brain tumors. The 
      agent responsible for the transmissibility of kuru and Creutzfeldt-Jakob disease 
      (CJD) remains uncharacterized despite recent interest in viroids and 
      abnormalities in replication of cell membranes. The epidemiological data on 
      multiple sclerosis suggests an exposure to an infectious agent at an early age of 
      life modified by the host response. No specific agent has been consistently 
      associated with multiple sclerosis. Amyotrophic lateral sclerosis (ALS), 
      Parkinson's disease, Mollaret's meningitis and Behcet's disease are other 
      examples where a virus is suspect but unproven. The ability of viruses to persist 
      in the host for months to years has linked many chronic neurologic diseases to an 
      infectious agent, enlarging the spectrum of disease caused by viruses.
FAU - Becker, L E
AU  - Becker LE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amyotrophic Lateral Sclerosis/etiology/microbiology
MH  - Animals
MH  - Central Nervous System Diseases/*etiology/microbiology
MH  - Child
MH  - Child, Preschool
MH  - Creutzfeldt-Jakob Syndrome/etiology/transmission
MH  - Humans
MH  - Kuru/etiology/transmission
MH  - Leukoencephalopathy, Progressive Multifocal/etiology
MH  - Measles/immunology
MH  - Middle Aged
MH  - Rubella/etiology
MH  - Slow Virus Diseases/classification/*etiology
MH  - Subacute Sclerosing Panencephalitis/etiology/immunology
RF  - 91
EDAT- 1977/05/01 00:00
MHDA- 1977/05/01 00:01
CRDT- 1977/05/01 00:00
PHST- 1977/05/01 00:00 [pubmed]
PHST- 1977/05/01 00:01 [medline]
PHST- 1977/05/01 00:00 [entrez]
PST - ppublish
SO  - Can J Neurol Sci. 1977 May;4(2):81-8.