PMID- 32282975 OWN - NLM STAT- MEDLINE DCOM- 20210625 LR - 20210625 IS - 1468-1331 (Electronic) IS - 1351-5101 (Linking) VI - 27 IP - 8 DP - 2020 Aug TI - Diagnostic potential of urinary monocyte chemoattractant protein-1 for Alzheimer's disease and amnestic mild cognitive impairment. PG - 1429-1435 LID - 10.1111/ene.14254 [doi] AB - BACKGROUND AND PURPOSE: The chemokine monocyte chemoattractant protein-1 (MCP-1) is involved in the pathogenesis of Alzheimer's disease (AD). This study aimed to investigate whether urinary MCP-1 can distinguish patients with AD, patients with amnestic mild cognitive impairment (aMCI) and cognitively normal (CN) subjects. METHODS: A total of 754 participants, including 97 patients with AD, 50 patients with aMCI and 84 age- and sex-matched CN controls as well as a cohort of 523 CN subjects of different ages, were enrolled from five hospitals located in different areas of China. Urinary MCP-1 levels were determined using enzyme-linked immunosorbent assays. The correlations between urinary MCP-1 levels and cognition test scores or age were analysed. The optimal diagnostic sensitivity and specificity were determined using receiver operating characteristic curve analysis. RESULTS: In the cohort of CN subjects of different ages, urinary MCP-1 levels increased with ageing and were correlated with age. The urinary MCP-1 levels were higher in females than in males. In the cohort composed of patients with AD, aMCI and age- and sex-matched CN controls, urinary MCP-1 levels were significantly higher in patients with AD and aMCI than in CN controls. There were no differences in urine MCP-1 levels between the AD group and the aMCI group. The urinary MCP-1 levels were correlated with the Mini-Mental State Examination scores and age, and were able to differentiate patients with AD and aMCI from CN subjects. CONCLUSIONS: Urinary MCP-1 is a potential biomarker for the diagnosis of AD and aMCI. CI - (c) 2020 European Academy of Neurology. FAU - Xu, Y AU - Xu Y AD - Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. AD - Department of Geriatrics, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China. FAU - Shen, Y-Y AU - Shen YY AD - Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. FAU - Zhang, X-P AU - Zhang XP AD - Department of General Practice, Chengdu Second People's Hospital, Chengdu, China. FAU - Gui, L AU - Gui L AD - Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China. FAU - Cai, M AU - Cai M AD - Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China. FAU - Peng, G-P AU - Peng GP AD - Department of Neurology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China. FAU - Pan, X-D AU - Pan XD AD - Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China. AD - Fujian Institute of Geriatrics, Fuzhou, China. AD - Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China. FAU - Zhang, J AU - Zhang J AD - Department of Geriatrics, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China. FAU - Gan, D AU - Gan D AD - Department of Geriatrics, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China. FAU - Li, B AU - Li B AD - Department of Health Management, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China. FAU - Cheng, H-P AU - Cheng HP AD - Department of Health Management, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China. FAU - Deng, J AU - Deng J AD - Department of Health Management, Daping Hospital, Third Military Medical University, Chongqing, China. FAU - Li, W-W AU - Li WW AD - Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. FAU - Zeng, G-H AU - Zeng GH AD - Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. FAU - Shi, A-Y AU - Shi AY AD - Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. FAU - Zhou, Z-H AU - Zhou ZH AD - Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China. FAU - Luo, B-Y AU - Luo BY AUID- ORCID: 0000-0002-9892-5778 AD - Department of Neurology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China. FAU - Chen, X-C AU - Chen XC AD - Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China. AD - Fujian Institute of Geriatrics, Fuzhou, China. AD - Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China. FAU - Wang, Y-J AU - Wang YJ AUID- ORCID: 0000-0002-6227-6112 AD - Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. AD - State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, China. AD - Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. LA - eng GR - Xm2017029/Chongqing Postdoctoral Science Projects/International GR - cstc2019jcyj-msxmX0117/Natural Science Foundation of Chongqing/International GR - 2017M623365/China Postdoctoral Science Foundation/International GR - 2016YFC1306401/Ministry of Science and Technology of the People's Republic of China/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200522 PL - England TA - Eur J Neurol JT - European journal of neurology JID - 9506311 RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) SB - IM MH - *Alzheimer Disease/diagnosis MH - Chemokine CCL2 MH - China MH - *Cognitive Dysfunction/diagnosis MH - Female MH - Humans MH - Male MH - Neuropsychological Tests OTO - NOTNLM OT - Alzheimer's disease OT - amnesic mild cognitive impairment OT - biomarker OT - cognitively normal subjects OT - diagnosis OT - monocyte chemoattractant protein-1 OT - urine EDAT- 2020/04/14 06:00 MHDA- 2021/06/29 06:00 CRDT- 2020/04/14 06:00 PHST- 2020/01/08 00:00 [received] PHST- 2020/03/31 00:00 [accepted] PHST- 2020/04/14 06:00 [pubmed] PHST- 2021/06/29 06:00 [medline] PHST- 2020/04/14 06:00 [entrez] AID - 10.1111/ene.14254 [doi] PST - ppublish SO - Eur J Neurol. 2020 Aug;27(8):1429-1435. doi: 10.1111/ene.14254. Epub 2020 May 22.