PMID- 32283599
OWN - NLM
STAT- MEDLINE
DCOM- 20201231
LR  - 20201231
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 56
IP  - 4
DP  - 2020 Apr 9
TI  - Identification of Cardiac MRI and Bio-Marker Thresholds for One-Year Survival in 
      Pre-Capillary Pulmonary Hypertension: Prospective Study.
LID - 10.3390/medicina56040167 [doi]
LID - 167
AB  - Background and objectives: Non-invasive imaging of the heart has an important 
      place in the diagnosis and management of pulmonary arterial hypertension (PAH). 
      The aim of this study was to establish the thresholds of cardiac magnetic 
      resonance imaging (CMRI)-derived biventricular deformation, function parameters, 
      and levels of N-terminal pro brain natriuretic peptide (NT-proBNP) for the 
      prediction of survival of pre-capillary pulmonary hypertension (PHprecap) 
      patients. Materials and Methods: In total, 64 incident PHprecap cases, who 
      underwent CMRI, were consecutively enrolled in a prospective cohort study. 
      Patients underwent a systemic evaluation, including measurement of NT-proBNP, 
      two-dimensional (2D) echocardiography, six-minute walk test (6MWT), CMRI with 
      feature tracking (FT), and right-heart catheterization (RHC). Patients were 
      divided into two groups according to one-year survival (survival and non-survival 
      groups). Survival analysis was performed. Results: One-year survival was 79.6%. 
      The distribution between age, sex, mean pulmonary artery pressure (mPAP), New 
      York Heart Association (NYHA) functional class, and 6MWT did not differ between 
      the groups. Survival was significantly lower in the PAH group associated with 
      connective tissue disease (CTD-PAH), where 44% (n = 4) of patients died during 
      the first year. Univariate analysis revealed that severely reduced 
      right-ventricle (RV) ejection fraction (EF) <25.5%, left-ventricle global 
      longitudinal strain (LV GLS) >-14.18%, and right pulmonary artery (RPA) relative 
      area change (RAC) <19%, and severely increased NT-proBNP level >1738 (ng/L) 
      indicate an increased risk of death in PH(precap) patients. Conclusions: Impaired 
      RV systolic function and LV global longitudinal strain, decrease of pulmonary 
      artery distensibility, and CTD-PAH etiology, together with high NT-proBNP level, 
      impair prognosis in pre-capillary PH patients. These findings are important for 
      the risk stratification and management of pre-capillary pulmonary hypertension 
      patients.
FAU - Padervinskiene, Lina
AU  - Padervinskiene L
AUID- ORCID: 0000-0003-3020-2810
AD  - Department of Radiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Hoppenot, Deimante
AU  - Hoppenot D
AD  - Department of Pulmonology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Krivickiene, Ausra
AU  - Krivickiene A
AD  - Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Gumauskiene, Birute
AU  - Gumauskiene B
AD  - Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Nedzelskiene, Irena
AU  - Nedzelskiene I
AD  - Department of Dental and Oral Diseases, Medical Academy, Lithuanian University of 
      Health Sciences, LT 44307 Kaunas, Lithuania.
FAU - Simkus, Paulius
AU  - Simkus P
AD  - Department of Radiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Miliauskas, Skaidrius
AU  - Miliauskas S
AD  - Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Jankauskas, Antanas
AU  - Jankauskas A
AD  - Department of Radiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Basevicius, Algidas
AU  - Basevicius A
AD  - Department of Radiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
FAU - Ereminiene, Egle
AU  - Ereminiene E
AD  - Department of Cardiology, Medical Academy, Lithuanian University of Health 
      Sciences, LT 44307 Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20200409
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Biomarkers/*analysis
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - Female
MH  - Gadolinium/therapeutic use
MH  - Humans
MH  - Hypertension, Pulmonary/blood/*complications
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/analysis/blood
MH  - Peptide Fragments/analysis/blood
MH  - Prognosis
MH  - Prospective Studies
MH  - Pulmonary Artery/*abnormalities/physiopathology
MH  - Survival Analysis
MH  - Weights and Measures/instrumentation
PMC - PMC7230686
OTO - NOTNLM
OT  - cardiac magnetic resonance
OT  - feature tracking
OT  - pulmonary hypertension
OT  - right ventricle
COIS- All authors declare that they have no competing interests.
EDAT- 2020/04/15 06:00
MHDA- 2021/01/01 06:00
PMCR- 2020/04/09
CRDT- 2020/04/15 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/03/23 00:00 [revised]
PHST- 2020/04/07 00:00 [accepted]
PHST- 2020/04/15 06:00 [entrez]
PHST- 2020/04/15 06:00 [pubmed]
PHST- 2021/01/01 06:00 [medline]
PHST- 2020/04/09 00:00 [pmc-release]
AID - medicina56040167 [pii]
AID - medicina-56-00167 [pii]
AID - 10.3390/medicina56040167 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2020 Apr 9;56(4):167. doi: 10.3390/medicina56040167.