PMID- 32284176
OWN - NLM
STAT- MEDLINE
DCOM- 20200828
LR  - 20200828
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 125
IP  - 11
DP  - 2020 Jun 1
TI  - Pregnancy Outcomes in Patients With Heart Disease in China.
PG  - 1718-1724
LID - S0002-9149(20)30222-8 [pii]
LID - 10.1016/j.amjcard.2020.02.043 [doi]
AB  - To analyze pregnancy outcomes of patients with heart disease in a single center 
      and to explore the risk factors of adverse outcomes. One thousand thirty-three 
      pregnant women with heart disease were retrospectively included from 2010 to 
      2017. We collected data of maternal, obstetric, and fetal outcomes. Among 1,086 
      pregnancies, 295 (27.1%) with congenital heart disease, 244 (22.5%) with 
      rheumatic heart disease, 387 (35.6%) with arrhythmia, and 55 (5.1%) with 
      cardiomyopathy. There were 8 (0.7%) maternal deaths. Risk factors of mortality 
      were New York Heart Association (NYHA) classification IV (p <0.001), cardiac 
      surgery during pregnancy (p <0.001), and general anesthesia (p <0.001). Maternal 
      cardiac complications occurred in 6.7% of women, with most in the cardiomyopathy 
      (26.0%) and rheumatic heart disease (32.9%) groups. Multivariate logistic 
      regression modeling was used to analyze the potential risk factors. NYHA 
      classification III and IV independently predicted worse maternal outcomes. 
      Peripartum intensive care unit admission rate was 10.2%. Admission to intensive 
      care unit was associated with NYHA classification II/III/IV, modified World 
      Health Organization (mWHO) classification II-III/III/IV, and cardiac surgery 
      during pregnancy. In conclusion, pregnancy with heart disease is at higher risk 
      of complications for both women and neonates. In our findings, maternal morbidity 
      is associated with NYHA classification and mWHO classification.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Hu, Jiaqi
AU  - Hu J
AD  - Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      People's Republic of China.
FAU - Ye, Yingxian
AU  - Ye Y
AD  - Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      People's Republic of China.
FAU - Lu, Anyi
AU  - Lu A
AD  - Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      People's Republic of China.
FAU - Chen, Liwen
AU  - Chen L
AD  - Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      People's Republic of China.
FAU - Mai, Yongjian
AU  - Mai Y
AD  - Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      People's Republic of China.
FAU - Huang, Guiting
AU  - Huang G
AD  - Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      People's Republic of China.
FAU - Wang, Sheng
AU  - Wang S
AD  - Department of Anesthesiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      People's Republic of China. Electronic address: shengwang_gz@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200316
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Abortion, Induced
MH  - Abortion, Spontaneous
MH  - Adult
MH  - Arrhythmias, Cardiac/*epidemiology
MH  - Cardiac Surgical Procedures
MH  - Cardiomyopathies/*epidemiology
MH  - China/epidemiology
MH  - Female
MH  - Heart Defects, Congenital/*epidemiology
MH  - Heart Valve Diseases/epidemiology
MH  - Humans
MH  - Hypertension, Pregnancy-Induced/epidemiology
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age
MH  - Logistic Models
MH  - *Maternal Mortality
MH  - Multivariate Analysis
MH  - *Perinatal Mortality
MH  - Postpartum Hemorrhage/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*epidemiology/surgery
MH  - Premature Birth/*epidemiology
MH  - Retrospective Studies
MH  - Rheumatic Heart Disease/*epidemiology
MH  - Severity of Illness Index
MH  - Venous Thromboembolism/epidemiology
MH  - Young Adult
EDAT- 2020/04/15 06:00
MHDA- 2020/08/29 06:00
CRDT- 2020/04/15 06:00
PHST- 2019/11/21 00:00 [received]
PHST- 2020/02/20 00:00 [revised]
PHST- 2020/02/24 00:00 [accepted]
PHST- 2020/04/15 06:00 [pubmed]
PHST- 2020/08/29 06:00 [medline]
PHST- 2020/04/15 06:00 [entrez]
AID - S0002-9149(20)30222-8 [pii]
AID - 10.1016/j.amjcard.2020.02.043 [doi]
PST - ppublish
SO  - Am J Cardiol. 2020 Jun 1;125(11):1718-1724. doi: 10.1016/j.amjcard.2020.02.043. 
      Epub 2020 Mar 16.