PMID- 32286436
OWN - NLM
STAT- MEDLINE
DCOM- 20201124
LR  - 20210414
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Apr 14
TI  - The establishment of neuron-specific enolase reference interval for the healthy 
      population in southwest China.
PG  - 6332
LID - 10.1038/s41598-020-63331-x [doi]
LID - 6332
AB  - To investigate and establish a reference interval (RI) of neuron-specific enolase 
      (NSE) in southwest China's healthy population by using the laboratory information 
      system database. A total of 86957 periodic health examination individuals of the 
      medical examination center in West China Hospital from 2016 to 2018 were included 
      in the study. We used the Box-Cox conversion combined with the Tukey method to 
      normalize the data and eliminate the outliers, and the normal distribution method 
      and the nonparametric method to estimate the 95% distribution RI. The NSE 95% 
      distribution RI we established in healthy populations in southwest China through 
      normal distribution and nonparametric method were 0-19.64 ng/ml and 
      0-20.46 ng/ml, respectively. The obtained RIs verification conformed to the 
      standard and was significantly different from the reagent instruction(P < 0.05). 
      The RI established by the nonparametric method was superior to the RI of the 
      normal distribution method and reagent instruction(P < 0.05). We initially 
      established an NSE RI that was suitable for the healthy southwest China 
      population. The Box-Cox conversion combined with the Tukey method and 
      nonparametric method is a reliable and straightforward indirect method for 
      reference interval acquisition, which is suitable for the promotion and 
      application of clinical laboratory.
FAU - Miao, Qiang
AU  - Miao Q
AD  - Department of Laboratory Medicine/ Research Center of Clinical Laboratory 
      Medicine, West China Hospital of Sichuan University, Chengdu, China.
FAU - Cai, Bei
AU  - Cai B
AD  - Department of Laboratory Medicine/ Research Center of Clinical Laboratory 
      Medicine, West China Hospital of Sichuan University, Chengdu, China.
FAU - Gao, Xuedan
AU  - Gao X
AD  - Department of Laboratory Medicine/ Research Center of Clinical Laboratory 
      Medicine, West China Hospital of Sichuan University, Chengdu, China.
FAU - Su, Zhenzhen
AU  - Su Z
AD  - Department of Laboratory Medicine/ Research Center of Clinical Laboratory 
      Medicine, West China Hospital of Sichuan University, Chengdu, China.
FAU - Zhang, Junlong
AU  - Zhang J
AD  - Department of Laboratory Medicine/ Research Center of Clinical Laboratory 
      Medicine, West China Hospital of Sichuan University, Chengdu, China. 
      immune_hx@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200414
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biological Variation, Population
MH  - Biomarkers/blood
MH  - China
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phosphopyruvate Hydratase/blood/*standards
MH  - Reference Standards
PMC - PMC7156405
COIS- The authors declare no competing interests.
EDAT- 2020/04/15 06:00
MHDA- 2020/11/25 06:00
PMCR- 2020/04/14
CRDT- 2020/04/15 06:00
PHST- 2019/11/12 00:00 [received]
PHST- 2020/03/26 00:00 [accepted]
PHST- 2020/04/15 06:00 [entrez]
PHST- 2020/04/15 06:00 [pubmed]
PHST- 2020/11/25 06:00 [medline]
PHST- 2020/04/14 00:00 [pmc-release]
AID - 10.1038/s41598-020-63331-x [pii]
AID - 63331 [pii]
AID - 10.1038/s41598-020-63331-x [doi]
PST - epublish
SO  - Sci Rep. 2020 Apr 14;10(1):6332. doi: 10.1038/s41598-020-63331-x.