PMID- 32286948
OWN - NLM
STAT- MEDLINE
DCOM- 20220105
LR  - 20220105
IS  - 1875-6212 (Electronic)
IS  - 1570-1611 (Linking)
VI  - 19
IP  - 4
DP  - 2021
TI  - The Significance of Renal Function in Response to Cardiac Resynchronisation 
      Therapy - A Piece of a Much Larger Puzzle.
PG  - 403-410
LID - 10.2174/1570161118666200414103432 [doi]
AB  - BACKGROUND: Although cardiac resynchronisation therapy (CRT) is an important 
      player in the treatment of patients with heart failure (HF), the proportion of 
      CRT patients with no improvement in either echocardiographic or clinical 
      parameters remains consistently high and accounts for about 30% despite meeting 
      CRT implantation criteria. Furthermore, in patients suffering from HF, renal 
      dysfunction accounts for as many as 30-60%. Accordingly, CRT may improve renal 
      function inducing a systemic haemodynamic benefit leading to increased renal 
      blood flow. OBJECTIVES: The aim of the present study was to evaluate the 
      importance of renal function in response to resynchronisation therapy during a 
      12-month follow-up period. MATERIALS AND METHODS: The study consisted of 46 HF 
      patients qualified for implantation of cardiac resynchronisation therapy 
      defibrillator (CRT-D). A CRT responder is defined as a person without chronic HF 
      exacerbations during observation whose physical efficiency has improved owing to 
      the New York Heart Association (NYHA) class improvement >/=1. RESULTS: A 
      statistically significant difference was noted between responders and 
      non-responders regarding creatinine level at the 3rd month (p=0.04) and, 
      particularly, at the 12th month (p=0.02) of follow-up (100+/-23 vs 139+/-78 mumol/l). 
      Moreover, there was a remarkable difference between both study groups with regard 
      to GFR CKD-EPI (glomerular filtration rate (GFR) assessed using the Chronic 
      Kidney Disease Epidemiology Collaboration (CKD-EPI) formula) at the 6th (p=0.03) 
      and 12th month (p=0.01) of follow-up. The reference values for initial creatinine 
      concentrations (101 mumol/l) as well as GFR CKDEPI (63 ml/min/1.73m2) were 
      empirically evaluated to predict favourable therapeutic CRT response. CONCLUSION: 
      Predictive value of GFR CKD-EPI and creatinine concentration for a positive 
      response to CRT was found relevant.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Debska-Kozlowska, Agnieszka
AU  - Debska-Kozlowska A
AD  - Department of Interventional Cardiology and Cardiac Arrhythmias, Medical 
      University of Lodz, Lodz, Poland.
FAU - Warchol, Izabela
AU  - Warchol I
AD  - Department of Interventional Cardiology and Cardiac Arrhythmias, Medical 
      University of Lodz, Lodz, Poland.
FAU - Ksiazczyk, Marcin
AU  - Ksiazczyk M
AD  - Department of Interventional Cardiology and Cardiac Arrhythmias, Medical 
      University of Lodz, Lodz, Poland.
FAU - Lubinski, Andrzej
AU  - Lubinski A
AD  - Department of Interventional Cardiology and Cardiac Arrhythmias, Medical 
      University of Lodz, Lodz, Poland.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Vasc Pharmacol
JT  - Current vascular pharmacology
JID - 101157208
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - *Heart Failure/therapy
MH  - Humans
MH  - *Kidney/physiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - CRT non-responders.
OT  - CRT responders
OT  - Cardiac resynchronisation therapy
OT  - chronic heart failure
OT  - chronic kidney disease
OT  - estimated glomerular filtration rate
EDAT- 2020/04/15 06:00
MHDA- 2022/01/06 06:00
CRDT- 2020/04/15 06:00
PHST- 2020/01/04 00:00 [received]
PHST- 2020/03/25 00:00 [revised]
PHST- 2020/03/27 00:00 [accepted]
PHST- 2020/04/15 06:00 [pubmed]
PHST- 2022/01/06 06:00 [medline]
PHST- 2020/04/15 06:00 [entrez]
AID - CVP-EPUB-105795 [pii]
AID - 10.2174/1570161118666200414103432 [doi]
PST - ppublish
SO  - Curr Vasc Pharmacol. 2021;19(4):403-410. doi: 10.2174/1570161118666200414103432.