PMID- 32288397
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1993-0437 (Electronic)
IS  - 1000-2413 (Print)
IS  - 1993-0437 (Linking)
VI  - 27
IP  - 3
DP  - 2012
TI  - Preparation and characterization of chitosan microsphere loading bovine serum 
      albumin.
PG  - 459-464
LID - 10.1007/s11595-012-0485-4 [doi]
AB  - To optimize the preparation process of chitosan microspheres and study its 
      loading capacity, chitosan microsphere was prepared by crosslinking with 
      glutaraldehyde, and bovine serum albumin (BSA) was absorbed onto chitosan 
      microsphere. Scanning electron microscope (SEM), Fourier transform infrared 
      spectroscopy (FITR), TA instruments and zeta potentiometer analyzer were used to 
      characterize the parameters with respect to size, thermal characters, morphology, 
      and zeta potential of the microspheres. The loading capability and in vitro 
      release tests were carried out. The results showed that chitosan microsphere with 
      particle size less than 10 mum and positively charged (+25.97+/-0.56 mV) can be 
      obtained under the aldehyde group to amino group ratio at 1:1. A loading capacity 
      of BSA at 28.63+/-0.15 g/100 g with corresponding loading efficiency at 72.01+/-1.44% 
      was obtained for chitosan microsphere. In vitro test revealed a burst release 
      followed by sustained-release profile.
CI  - (c) Wuhan University of Technology and Springer-Verlag Berlin Heidelberg 2012.
FAU - Sun, Qingshen
AU  - Sun Q
AD  - 1Key Laboratory of Functional Inorganic Material Chemistry, Heilongjiang 
      University, Ministry of Education, Harbin, 150080 China. GRID: grid.412067.6. 
      ISNI: 0000000417601291
AD  - 2University Key Laboratory of Microbiology, College of Life Science, Heilongjiang 
      University, Harbin, 150080 China. GRID: grid.412067.6. ISNI: 0000000417601291
FAU - Han, Dequan
AU  - Han D
AD  - 2University Key Laboratory of Microbiology, College of Life Science, Heilongjiang 
      University, Harbin, 150080 China. GRID: grid.412067.6. ISNI: 0000000417601291
FAU - Lei, Hong
AU  - Lei H
AD  - 2University Key Laboratory of Microbiology, College of Life Science, Heilongjiang 
      University, Harbin, 150080 China. GRID: grid.412067.6. ISNI: 0000000417601291
FAU - Zhao, Kai
AU  - Zhao K
AD  - 2University Key Laboratory of Microbiology, College of Life Science, Heilongjiang 
      University, Harbin, 150080 China. GRID: grid.412067.6. ISNI: 0000000417601291
FAU - Zhu, Li
AU  - Zhu L
AD  - 2University Key Laboratory of Microbiology, College of Life Science, Heilongjiang 
      University, Harbin, 150080 China. GRID: grid.412067.6. ISNI: 0000000417601291
FAU - Li, Xiaodi
AU  - Li X
AD  - 2University Key Laboratory of Microbiology, College of Life Science, Heilongjiang 
      University, Harbin, 150080 China. GRID: grid.412067.6. ISNI: 0000000417601291
FAU - Fu, Honggang
AU  - Fu H
AD  - 1Key Laboratory of Functional Inorganic Material Chemistry, Heilongjiang 
      University, Ministry of Education, Harbin, 150080 China. GRID: grid.412067.6. 
      ISNI: 0000000417601291
LA  - eng
PT  - Journal Article
DEP - 20120609
PL  - China
TA  - J Wuhan Univ Technol Mater Sci Ed
JT  - Journal of Wuhan University of Technology. Materials science edition
JID - 101765285
PMC - PMC7111542
OTO - NOTNLM
OT  - bovine serum albumin
OT  - chitosan microsphere
OT  - crosslinking
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2020/04/01
CRDT- 2020/04/15 06:00
PHST- 2010/11/10 00:00 [received]
PHST- 2012/01/13 00:00 [accepted]
PHST- 2020/04/15 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 485 [pii]
AID - 10.1007/s11595-012-0485-4 [doi]
PST - ppublish
SO  - J Wuhan Univ Technol Mater Sci Ed. 2012;27(3):459-464. doi: 
      10.1007/s11595-012-0485-4. Epub 2012 Jun 9.