PMID- 32289611
OWN - NLM
STAT- MEDLINE
DCOM- 20201016
LR  - 20201016
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 131
DP  - 2020 Aug
TI  - High genetic diversity of Chinese porcine reproductive and respiratory syndrome 
      viruses from 2016 to 2019.
PG  - 38-42
LID - S0034-5288(19)31027-6 [pii]
LID - 10.1016/j.rvsc.2020.04.004 [doi]
AB  - High genetic diversity and limited cross-protection are two major reasons for 
      ineffective control of porcine reproductive and respiratory syndrome virus 
      (PRRSV) infection. Therefore, it's important to dynamically monitor the 
      prevalence of PRRSV for adopting appropriate control strategy. In this study, we 
      analyzed PRRSV infection by detecting 712 clinical samples collected from 2016 to 
      2019 in China. Totally 100 samples were detected as PRRSV positive, including 2 
      and 98 samples were infected with PRRSV1 and PRRSV2, respectively. In addition, 
      two out of the 98 PRRSV2 positive samples were co-infected with two distinct 
      viruses. ORF5-based phylogenetic analysis showed that JXA1-like HP-PRRSV2 
      (lineage 8) and NADC30-like PRRSV2 (lineage 1) isolates are currently 
      predominant, but QYYZ-like PRRSV2, CH-1a-like PRRSV2 and PRRSV1 isolates also 
      co-exist in Chinese swine herds. In addition, two commercial MLV-derived viruses 
      (TJM-F92-like and JXA1-R-like) were frequently detected. GP5 alignment also 
      detected insertion and deletion in the extravirion domain. Our study presents the 
      up-to-date PRRSV infection status and highlights the high genetic diversity of 
      PRRSV currently circulating in China.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Chen, Nanhua
AU  - Chen N
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China; Comparative Medicine Research Institute, Yangzhou University, Yangzhou, 
      Jiangsu 225009, PR China; Jiangsu Co-innovation Center for Prevention and Control 
      of Important Animal Infectious Diseases and Zoonoses, China; Joint International 
      Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, Jiangsu 
      225009, PR China. Electronic address: hnchen@yzu.edu.cn.
FAU - Xiao, Yanzhao
AU  - Xiao Y
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China.
FAU - Ye, Mengxue
AU  - Ye M
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China.
FAU - Li, Xinshuai
AU  - Li X
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China.
FAU - Li, Shubin
AU  - Li S
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China.
FAU - Xie, Ningjun
AU  - Xie N
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China.
FAU - Wei, Yue
AU  - Wei Y
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China.
FAU - Wang, Jialin
AU  - Wang J
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China.
FAU - Zhu, Jianzhong
AU  - Zhu J
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR 
      China; Comparative Medicine Research Institute, Yangzhou University, Yangzhou, 
      Jiangsu 225009, PR China; Jiangsu Co-innovation Center for Prevention and Control 
      of Important Animal Infectious Diseases and Zoonoses, China; Joint International 
      Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, Jiangsu 
      225009, PR China. Electronic address: jzzhu@yzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200408
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
SB  - IM
MH  - Animals
MH  - China/epidemiology
MH  - *Genetic Variation
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - Sequence Deletion
MH  - Swine
OTO - NOTNLM
OT  - Genetic diversity
OT  - MLV-derived viruses
OT  - ORF5 gene
OT  - Porcine reproductive and respiratory syndrome virus (PRRSV)
COIS- Declaration of Competing Interest The authors declare no competing interests.
EDAT- 2020/04/15 06:00
MHDA- 2020/10/21 06:00
CRDT- 2020/04/15 06:00
PHST- 2019/10/06 00:00 [received]
PHST- 2020/03/07 00:00 [revised]
PHST- 2020/04/02 00:00 [accepted]
PHST- 2020/04/15 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/04/15 06:00 [entrez]
AID - S0034-5288(19)31027-6 [pii]
AID - 10.1016/j.rvsc.2020.04.004 [doi]
PST - ppublish
SO  - Res Vet Sci. 2020 Aug;131:38-42. doi: 10.1016/j.rvsc.2020.04.004. Epub 2020 Apr 
      8.